dc.contributor.author |
Gerendai, Ida |
|
dc.contributor.author |
Banczerowski, Péter |
|
dc.contributor.author |
Csernus, Valér |
|
dc.contributor.author |
Halász, Béla |
|
dc.date.accessioned |
2016-10-12T12:04:30Z |
|
dc.date.available |
2016-10-12T12:04:30Z |
|
dc.date.issued |
2007 |
|
dc.identifier |
33845786510 |
|
dc.identifier.citation |
pagination=21-27;
journalVolume=131;
journalIssueNumber=1-2;
journalTitle=AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/1323 |
|
dc.identifier.uri |
doi:10.1016/j.autneu.2006.06.002 |
|
dc.description.abstract |
Testosterone secretion by Leydig cells is affected by interleukin-1beta (IL-1beta). The aim of the present study was to investigate whether partial denervation of the testis or local administration of a serotonin (5-HT) receptor antagonist could alter the changes in testicular steoidogenesis induced by IL-1beta. Intratesticular administration of IL-1beta was combined with vasectomy or local injection of ketanserin (5-HT type 2 receptor antagonist) in immature hemicastrated rats and the effect of the interventions on testicular steroidogenesis was studied. One day after treatment with local injection of IL-1beta induced a significant rise in testosterone secretion that could be prevented by vasectomy (that also means transection of the inferior spermatic nerve). In a model in which neither IL-1beta nor ketanserin interfered with steroidogenesis, administration of the receptor antagonist just prior to IL-1beta treatment significantly reduced testosterone secretion. Data indicate interaction between testicular nerves and IL-1beta action and interaction between testicular 5-HT2 receptors and local effect of IL-1beta on testosterone secretion. |
|
dc.relation.ispartof |
urn:issn:1566-0702 |
|
dc.title |
Innervation And Serotoninergic Receptors of The Testis Interact With Local Action of Interleukin-1beta on Steroidogenesis. |
|
dc.type |
Journal Article |
|
dc.date.updated |
2015-02-04T10:33:33Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
1089566 |
|
dc.identifier.wos |
000243713200003 |
|
dc.identifier.pubmed |
16829209 |
|
dc.contributor.department |
Pécsi Tudományegyetem |
|
dc.contributor.department |
SE/AOK/I/Humánmorfológiai és Fejlődésbiológiai Intézet |
|
dc.contributor.department |
MTA TKI/MTA-SE Neuromorfológiai és Neuroendokrin Kutatócsoport (2006-ig: MTA-SE Neuroendokrin Kutatócsoport) |
|
dc.contributor.institution |
Pécsi Tudományegyetem |
|
dc.contributor.institution |
Semmelweis Egyetem |
|