dc.contributor.author |
Lukáts, Ákos |
|
dc.contributor.author |
Dkhissi-Benyahya O, |
|
dc.contributor.author |
Szepessy, Zsuzsanna |
|
dc.contributor.author |
Röhlich, Pál |
|
dc.contributor.author |
Vigh, Béla |
|
dc.contributor.author |
Szél, Ágoston |
|
dc.date.accessioned |
2015-02-25T10:21:13Z |
|
dc.date.available |
2015-02-25T10:21:13Z |
|
dc.date.issued |
2002 |
|
dc.identifier |
0036295181 |
|
dc.identifier.citation |
pagination=2468-2473;
journalVolume=43;
journalIssueNumber=7;
journalTitle=INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/1376 |
|
dc.description.abstract |
PURPOSE. To decide whether the identical topography of short- and
middle-wavelength cone photoreceptors in two species of rodents
reflects the presence of both opsins in all cone cells.
METHODS. Double-label immunocytochemistry, using antibodies directed
against short-wavelength (S)- and middle- to long-wavelength
(M/L)-sensitive opsin were used to determine the presence of visual
pigments in cones of two species of rodents, the Siberian hamster
(Phodopus sungorus) and the pouched Mouse (Saccostomus campestris) from
South Africa. Topographical distribution was determined from retinal
whole-mounts. and the colocalization of visual pigments was examined
using confocal laser scanning microscopy. Opsin colocalization was also
confirmed in consecutive semithin tangential sections.
RESULTS. The immunocytochemical results demonstrate that in both the
Siberian hamster and the pouched mouse all retinal cones contain two
visual pigments. No dorsoventral gradient in the differential
expression of the two opsins is observed.
CONCLUSIONS. The retina of the Siberian hamster and the pouched mouse
is the first example to show a uniform coexpression of M and S cone
opsins in all cones, without any topographical gradient in opsin
expression. This finding makes these two species good models for the
study of molecular control mechanisms in opsin coexpression in rodents,
and renders them suitable as sources of dual cones for future
investigations on the role and neural connections of this cone type. |
|
dc.relation.ispartof |
urn:issn:0146-0404 |
|
dc.title |
Visual pigment coexpression in all cones of two rodents, the Siberian hamster, and the pouched mouse |
|
dc.type |
Journal Article |
|
dc.date.updated |
2015-02-10T11:44:57Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
1135147 |
|
dc.identifier.wos |
000176482300057 |
|
dc.identifier.pubmed |
12091452 |
|
dc.contributor.department |
SE/AOK/I/Humánmorfológiai és Fejlődésbiológiai Intézet |
|
dc.contributor.institution |
Semmelweis Egyetem |
|