dc.contributor.author |
Vincze E |
|
dc.contributor.author |
Kántor Orsolya |
|
dc.contributor.author |
Kausz Mária |
|
dc.contributor.author |
Nemeth J |
|
dc.contributor.author |
Arimura A |
|
dc.contributor.author |
Köves Katalin |
|
dc.date.accessioned |
2015-03-10T09:46:18Z |
|
dc.date.available |
2015-03-10T09:46:18Z |
|
dc.date.issued |
2001 |
|
dc.identifier.citation |
pagination=99-103;journalVolume=95;journalIssueNumber=1-6;journalTitle=JOURNAL OF PHYSIOLOGY (PARIS 1992-); |
hu |
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/1394 |
|
dc.identifier.uri |
doi:10.1016/S0928-4257(01)00014-6 |
|
dc.description.abstract |
Bioactive peptides have an important multifunctional role in the
gastrointestinal tract. In the present study we have
investigated the dynamism of the appearance of PACAP (pituitary
adenylate cyclase activating polypeptide), VIP (vasoactive
intestinal polypeptide), gastrin, and secretin
immunoreactivities in human foregut derivates during the
ontogenesis using an immunohistochemical approach. None of these
peptides were observed in the foregut derivates of an 8-week-old
embryo. VIP immunoreactive nerve fibers appeared by the 11th
week in the smooth muscle layers of the stomach. No other
peptide immunoreactivities were observed of this stage. In 18-
and 20-week old fetuses PACAP, secretin, and gastrin
immunoreactive cells appeared in the developing glands of the
stomach. In the duodenum gastrin immunoreactivity was present in
the Lieberkuhn's glands and secretin immunoreactive cells were
seen between the surface epithelial cells. In the pancreas
secretin immunoreactivity was found in the Langerhans islets;
however, PACAP immunreactivity was observed in the exocrine
portion. The distribution of VIP fibers did not change during
the fetal life and it was similar to the adult pattern.
According to our results the appearance of PACAP, secretin, and
gastrin in the developing glands suggests their role in the
proliferation and differentiation of the epithelial derivates. |
hu |
dc.relation.ispartof |
urn:issn:0928-4257 |
|
dc.title |
Comparative study on the appearance of various bioactive peptides in foregut derivates during the ontogenesis |
hu |
dc.type |
Journal Article |
hu |
dc.date.updated |
2015-02-12T12:25:08Z |
|
dc.language.rfc3066 |
en |
hu |
dc.identifier.mtmt |
1503242 |
|
dc.identifier.wos |
000171904600014 |
|
dc.identifier.pubmed |
11595424 |
|
dc.contributor.department |
SE/AOK/I/II. Sz. Patológiai Intézet |
|
dc.contributor.department |
SE/AOK/I/Humánmorfológiai és Fejlődésbiológiai Intézet |
|
dc.contributor.institution |
Semmelweis Egyetem |
|