dc.contributor.author |
Varga, Marina |
|
dc.contributor.author |
Görög, Dénes |
|
dc.contributor.author |
Kari D |
|
dc.contributor.author |
Kornyei E |
|
dc.contributor.author |
Kis, Éva PhD |
|
dc.contributor.author |
Turyne HJ |
|
dc.contributor.author |
Jankovics I |
|
dc.contributor.author |
Péter, Antal |
|
dc.contributor.author |
Toronyi, Éva |
|
dc.contributor.author |
Sárváry, Enikő |
|
dc.contributor.author |
Fazakas, János |
|
dc.contributor.author |
Reusz, György |
|
dc.date.accessioned |
2015-04-14T13:44:00Z |
|
dc.date.available |
2015-04-14T13:44:00Z |
|
dc.date.issued |
2011 |
|
dc.identifier |
79957599903 |
|
dc.identifier.citation |
pagination=1233-1235;
journalVolume=43;
journalIssueNumber=4;
journalTitle=TRANSPLANTATION PROCEEDINGS; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/1576 |
|
dc.identifier.uri |
doi:10.1016/j.transproceed.2011.03.067 |
|
dc.description.abstract |
BACKGROUND: Cytomegalovirus (CMV) is endemic throughout the world, affecting most of the population, but the seroprevalence of CMV is known to vary among countries. CMV causes a mild infection in persons with intact immunity; however, CMV infection in organ transplantation is associated with significant morbidity and mortality. The present retrospective study was designed to evaluate the age-, gender-, and blood group-adjusted CMV seroprevalence among solid organ donors, representing fairly the overall Hungarian population (according to Hungarian Central Statistic Institute). This information is important for calculating risk-factors for CMV-seronegative recipients. No nationwide estimates of CMV seroprevalence in Hungary (as a representative of Eastern Middle Europe) have been published yet. METHODS: We investigated 2070 organ donors for CMV seroprevalence by measuring the CMV-specific immunoglobulin G. The donors were divided into 3 age groups (2-20, 21-50, and 51-70 years old). A study was also conducted on a fourth group consisting of 200 residents from an old age home. CMV seroprevalence differences were searched according to age-, gender- and blood-group distribution. RESULTS: The CMV seroprevalence of organ donors is 85% and of all investigated persons is 86%. The age-specific prevalence increases, starting from 72% in the first group to 99% in the fourth group. Seroprevalence of females was found to be significantly higher than of males (P = .0001). CONCLUSION: We have shown that the overall CMV seroprevalence in the Hungarian population is moderately high at 86%. The opportunity for CMV-seronegative recipients to get a graft from a seronegative donor is statistically only 2%. The seroprevalence of the youngest age group is 72% and so it can be concluded that the Hungarian population acquires the infection mainly in childhood or in the early adulthood. Female gender is a risk factor for CMV infection. This fact must be taken into consideration during the planning of patients' follow-up, prophylaxis, and therapy. |
|
dc.relation.ispartof |
urn:issn:0041-1345 |
|
dc.title |
Cytomegalovirus seroprevalence among solid organ donors in hungary: correlations with age, gender, and blood group |
|
dc.type |
Journal Article |
|
dc.date.updated |
2015-03-13T10:10:59Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
1608375 |
|
dc.identifier.wos |
000291289400075 |
|
dc.identifier.pubmed |
21620098 |
|
dc.contributor.department |
SE/AOK/K/I. Sz. Gyermekgyógyászati Klinika |
|
dc.contributor.department |
SE/AOK/K/Transzplantációs és Sebészeti Klinika |
|
dc.contributor.institution |
Semmelweis Egyetem |
|