Kivonat:
Th17 cells are the newly described subset of the CD4 <sup>+
</sup> T lymphocytes. Activated Th17 cells are characterized by
their ability to produce IL-17A and other pro-inflammatory
cytokines. IL-17A regulates immune function through its cell-
surface receptor expressed on epithelial-and endothelial cells,
fibroblasts and leukocytes by promoting neutrophil recruitment
and releasing further pro-inflammatory mediators. Failures of
the susceptible balance of the immunoregulation may lead to
unchecked immune response and autoimmune diseases. The central
role of Th17 cells and cytokines produced by Th17 cells were
confirmed in a wide variety of human autoimmune diseases,
including rheumatoid arthritis. Recently Th17 cells and its
cytokines come into the focus of immunological research as
potential therapeutic targets.