dc.contributor.author |
Lovász, Barbara Dorottya |
|
dc.contributor.author |
Lakatos, László |
|
dc.contributor.author |
Horvath A |
|
dc.contributor.author |
Pandur T |
|
dc.contributor.author |
Erdelyi Z |
|
dc.contributor.author |
Balogh M |
|
dc.contributor.author |
Szipocs I |
|
dc.contributor.author |
Végh, Zsuzsanna |
|
dc.contributor.author |
Veres, Gábor |
|
dc.contributor.author |
Müller, Katalin Eszter |
|
dc.contributor.author |
Golovics, Petra Anna |
|
dc.contributor.author |
Kiss, Lajos Sándor |
|
dc.contributor.author |
Mandel MD |
|
dc.contributor.author |
Lakatos, Péter László |
|
dc.date.accessioned |
2015-06-12T11:07:01Z |
|
dc.date.available |
2015-06-12T11:07:01Z |
|
dc.date.issued |
2014 |
|
dc.identifier |
84898927860 |
|
dc.identifier.citation |
pagination=405-411;
journalVolume=46;
journalIssueNumber=5;
journalTitle=DIGESTIVE AND LIVER DISEASE; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/1619 |
|
dc.identifier.uri |
doi:10.1016/j.dld.2013.12.013 |
|
dc.description.abstract |
BACKGROUND:
Limited data are available on paediatric inflammatory bowel diseases in Eastern Europe. Our aim was to analyse disease characteristics in the population-based Veszprem province database between 1977 and 2011.
METHODS:
187 (10.5%, ulcerative colitis/Crohn's disease/undetermined colitis: 88/95/4) out of 1565 incident patients were diagnosed with a paediatric onset in this population-based prospective inception cohort.
RESULTS:
The incidence of Crohn's disease and ulcerative colitis increased from 0 and 0.7 in 1977-1981 to 7.2 and 5.2 in 2007-2011 per 100,000 person years. Ileocolonic location (45%) and inflammatory disease behaviour (61%) were most frequent in Crohn's disease, while azathioprine use was frequent (66%) and surgical resection rates were high (33% at 5 years) in cases with paediatric onset. In ulcerative colitis, 34% of patients were diagnosed with extensive disease, with high rates of disease extension (26% and 41% at 5 and 10 years), fulminant episodes (19.3%) and systemic steroid use (52.3%). The cumulative rate of colectomy was low (6.9%).
CONCLUSIONS:
The incidence of paediatric inflammatory bowel diseases has rapidly increased in the last three decades in Western Hungary. Ileocolonic disease and a need for azathioprine were characteristic in paediatric Crohn's disease, while paediatric onset ulcerative colitis was characterised by extensive disease and disease extension, while the need for colectomy was low. |
|
dc.relation.ispartof |
urn:issn:1590-8658 |
|
dc.title |
Incidence Rates and Disease Course of Pediatric IBD in Western Hungary Between 1977 and 2011 |
|
dc.type |
Journal Article |
|
dc.date.updated |
2015-03-25T09:30:05Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
2477829 |
|
dc.identifier.wos |
000334512500007 |
|
dc.identifier.pubmed |
24495511 |
|
dc.contributor.department |
SE/AOK/K/I. Sz. Gyermekgyógyászati Klinika |
|
dc.contributor.department |
SE/AOK/K/I. Sz. Belgyógyászati Klinika |
|
dc.contributor.institution |
Semmelweis Egyetem |
|