Show simple item record Meleddu Rita, Distinto Simona, Corona Angela, Bianco Giulia, Cannas Valeria, Mátyus, Péter Bogdán, Dóra 2015-03-28T18:15:48Z 2015-03-28T18:15:48Z 2015
dc.identifier.citation pagination=452-460; journalVolume=93; journalTitle=EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY;
dc.identifier.uri doi:10.1016/j.ejmech.2015.02.032
dc.description.abstract The HIV-1 Reverse Transcriptase (RT) is a validated and deeply explored biol. target for the treatment of AIDS. However, only drugs targeting the RT-assocd. DNA polymerase (DP) function have been approved for clin. use. We designed and synthesized a new generation of HIV-1 RT inhibitors, based on the (3Z)-3-(2-[4-(aryl)-1,3-thiazol-2-yl]hydrazin-1-ylidene)-2,3-dihydro-1H-indol-2-one scaffold. These compds. are active towards both RT-assocd. functions, DNA polymerase and RNase H. The structure, biol. activity and mode of action of the new derivs. have been investigated. In particular, the nature of the arom. group in the position 4 of the thiazole ring plays a key role in the modulation of the activity towards the two RT-assocd. functions. [on SciFinder(R)]
dc.relation.ispartof urn:issn:0223-5234
dc.title (3Z)-3-(2-[4-(aryl)-1,3-thiazol-2-yl]hydrazin-1-ylidene)-2,3-dihydro-1H-indol-2-one derivatives as dual inhibitors of HIV-1 reverse transcriptase.
dc.type Journal Article 2015-03-28T18:15:11Z
dc.language.rfc3066 en
dc.identifier.mtmt 2852881
dc.contributor.department SE/GYTK/Szerves Vegytani Intézet
dc.contributor.institution Semmelweis Egyetem
dc.mtmt.swordnote N1 CAPLUS AN 2015:313876(Journal; Online Computer File)

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