Show simple item record Rosero, Olivér Ónody, Péter Zoltán Stangl R Turóczi, Zsolt Fülöp, András Garbaisz, Dávid Lotz, Gábor Harsányi, László Szijártó, Attila 2015-04-13T09:04:42Z 2015-04-13T09:04:42Z 2014
dc.identifier.citation pagination=427-437; journalVolume=187; journalIssueNumber=2; journalTitle=JOURNAL OF SURGICAL RESEARCH;
dc.identifier.uri doi:10.1016/j.jss.2013.10.035
dc.description.abstract BACKGROUND: Mesenteric ischemia is a serious clinical condition requiring immediate surgical intervention. The unavoidable ischemic-reperfusion (IR) injury may be ameliorated using the appropriate postconditioning protocol. The aim of the present study was to investigate the optimal postconditioning algorithm in a rat model of intestinal ischemic-reperfusion injury. MATERIALS AND METHODS: Male Wistar rats were randomized into five groups (n = 10), one sham-operated, one IR, and three postconditioned groups, each with different protocols. The animals were subjected to 60 min of mesenteric ischemia, followed by 60 min of reperfusion. Postconditioning was applied at the onset of reperfusion using three different algorithms. Arterial pressure and mucosal microcirculation were monitored throughout the experiment. Mesenteric pH was determined at the early phase of reperfusion. Blood and tissue samples were taken at the end of reperfusion for histologic evaluation, serum lactate dehydrogenase, serum creatine kinase, serum tumor necrosis factor-alpha, serum interleukin-6, detailed mucosal antioxidant, and scavenger capacity assays. RESULTS: The shorter and intermediate length cycles of postconditioning enhanced mucosal microcirculation and redox state and significantly delayed the normalization of mesenteric pH. Furthermore, milder histopathologic lesions and lower concentrations of serum necroenzymes and proinflammatory cytokines were detected compared with the IR group. The protective effect of postconditioning using longer cycles could only be seen in a tendentious manner. CONCLUSIONS: In a rat model of intestinal ischemia-reperfusion, the shorter and intermediate length cycles of postconditioning proved to be more effective than the use of longer cycles.
dc.relation.ispartof urn:issn:0022-4804
dc.title Postconditioning of the small intestine: which is the most effective algorithm in a rat model?
dc.type Journal Article 2015-04-10T11:47:57Z
dc.language.rfc3066 en
dc.identifier.mtmt 2492343
dc.identifier.wos 000332770600010
dc.identifier.pubmed 24238973
dc.contributor.department SE/AOK/K/I. Sz. Sebészeti Klinika
dc.contributor.department SE/AOK/I/II. Sz. Patológiai Intézet
dc.contributor.institution Semmelweis Egyetem

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