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dc.contributor.author Huusko JM
dc.contributor.author Karjalainen MK
dc.contributor.author Mahlman M
dc.contributor.author Haataja R
dc.contributor.author Kari MA
dc.contributor.author Toldi, Gergely
dc.contributor.author Andersson S
dc.contributor.author Tammela O
dc.contributor.author Ramet M
dc.contributor.author Lavoie PM
dc.contributor.author Hallman M
dc.contributor.author Gen-BPD Study Group
dc.date.accessioned 2015-06-11T11:49:27Z
dc.date.available 2015-06-11T11:49:27Z
dc.date.issued 2014
dc.identifier 84923864877
dc.identifier.citation pagination=120; journalVolume=15; journalTitle=BMC MEDICAL GENETICS;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/1779
dc.identifier.uri doi:10.1186/s12881-014-0120-7
dc.description.abstract BACKGROUND: Bronchopulmonary dysplasia (BPD) is a common chronic lung disease associated with very preterm birth. The major risk factors include lung inflammation and lung immaturity. In addition, genetic factors play an important role in susceptibility to moderate-to-severe BPD. In this study, the aim was to investigate whether common polymorphisms of specific genes that are involved in inflammation or differentiation of the lung have influence on BPD susceptibility. METHODS: Genes encoding interleukin-6 (IL6) and its receptors (IL6R and IL6ST), IL-10 (IL10), tumor necrosis factor (TNF), and glucocorticoid receptor (NR3C1) were assessed for associations with moderate-to-severe BPD susceptibility. Five IL6, nine IL6R, four IL6ST, one IL10, two TNF, and 23 NR3C1 single nucleotide polymorphisms (SNPs) were analyzed in very preterm infants born in northern Finland (56 cases and 197 controls) and Canada (58 cases and 68 controls). IL-6, TNF and gp130 contents in umbilical cord blood, collected from very preterm infants, were studied for associations with the polymorphisms. Epistasis (i.e., interactions between SNPs in BPD susceptibility) was also examined. SNPs showing suggestive associations were analyzed in additional replication populations from Finland (39 cases and 188 controls) and Hungary (29 cases and 40 controls). RESULTS: None of the studied SNPs were associated with BPD nor were the IL6, TNF or IL6ST SNPs associated with cord blood IL-6, TNF and gp130, respectively. However, epistasis analysis suggested that SNPs in IL6ST and IL10 were associated interactively with risk of BPD in the northern Finnish population; however, this finding did not remain significant after correction for multiple testing and the finding was not replicated in the other populations. CONCLUSIONS: We conclude that the analyzed SNPs within IL6, IL6R, IL6ST, IL10, TNF, and NR3C1 were not associated with BPD. Furthermore, there was no evidence that the studied SNPs directly contribute to the cord blood protein contents.
dc.relation.ispartof urn:issn:1471-2350
dc.title A study of genes encoding cytokines (IL6, IL10, TNF), cytokine receptors (IL6R, IL6ST), and glucocorticoid receptor (NR3C1) and susceptibility to bronchopulmonary dysplasia
dc.type Journal Article
dc.date.updated 2015-05-06T09:14:57Z
dc.language.rfc3066 en
dc.identifier.mtmt 2849431
dc.identifier.wos 000345714200001
dc.identifier.pubmed 25409741
dc.contributor.department SE/AOK/K/I. Sz. Gyermekgyógyászati Klinika
dc.contributor.institution Semmelweis Egyetem


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