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dc.contributor.author Vincze, Krisztina
dc.contributor.author Kováts, Zsuzsanna
dc.contributor.author Cseh, Áron
dc.contributor.author Pásti, Krisztina
dc.contributor.author Kiss, Emese
dc.contributor.author Polgar A
dc.contributor.author Vásárhelyi, Barna
dc.contributor.author Szabó, Attila
dc.contributor.author Bohács, Anikó
dc.contributor.author Tamási, Lilla
dc.contributor.author Losonczy, György
dc.contributor.author Müller, Veronika
dc.date.accessioned 2015-06-12T11:12:34Z
dc.date.available 2015-06-12T11:12:34Z
dc.date.issued 2014
dc.identifier 84899478631
dc.identifier.citation pagination=766-774; journalVolume=108; journalIssueNumber=5; journalTitle=RESPIRATORY MEDICINE;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/1817
dc.identifier.uri doi:10.1016/j.rmed.2014.02.006
dc.description.abstract INTRODUCTION: Systemic lupus erythematosus (SLE) is an autoimmune disease involving several organs, including the lungs. Previous results confirmed changes of peripheral T cell subsets in lupus patients; however no data are available about their possible relationship with pulmonary involvement. OBJECTIVE: To determine pulmonary manifestations and potential relationship in changes of peripheral CD4+ T cell subsets. METHODS: Patients with SLE (N = 28) were enrolled in complex pulmonary examination. Patients were divided into groups with pleuropulmonary manifestations (SLEpulmN = 13 age: 44.9 +/- 3.3 years, female: male = 11:2) or without (SLEcN = 15 age: 27.2 +/- 3.7 years, female: male = 12:3). Peripheral blood was taken for T helper (Th)1, Th2, Th17, CD4+CD25hi+ and regulatory T (Treg: CD4+CD25hi+ CD127-) cell analysis from SLE patients and healthy volunteers (controls, N = 40). RESULTS: SLEpulm patients were older, had more pulmonary symptoms and significantly decreased pO2 as compared to SLEc group. Ventilatory disorder was present in 92% of SLEpulm patients, with significantly decreased lung volumes, signs of airway involvement and decrease in DLco. Significant increase in Th1/Th2, while decrease in Th17/Treg ratios was present in all SLE compared to controls. In SLEpulm CD4+CD25hi+ subset without changes in Treg number was significantly increased as compared to SLEc and this subgroup of T cell showed significant positive correlation with dynamic lung function parameters and DLco (p < 0.05). CONCLUSION: In lupus patients pleuropulmonary manifestations are prevalent and lung function and blood gas measurements should be regularly performed in the daily clinical assessment. Significant increase of activated CD4+CD25hi+ T cells, but not Treg is associated with decreased lung function parameters in SLEpulm patients.
dc.relation.ispartof urn:issn:0954-6111
dc.title Peripheral CD4+ cell prevalence and pleuropulmonary manifestations in systemic lupus erythematosus patients.
dc.type Journal Article
dc.date.updated 2015-05-07T08:43:20Z
dc.language.rfc3066 en
dc.identifier.mtmt 2554146
dc.identifier.pubmed 24613209
dc.contributor.department SE/AOK/K/I. Sz. Gyermekgyógyászati Klinika
dc.contributor.department SE/AOK/K/Pulmonológiai Klinika
dc.contributor.institution Semmelweis Egyetem


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