dc.contributor.author |
Bikov András |
|
dc.contributor.author |
Böcskei Renáta |
|
dc.contributor.author |
Eszes Noémi |
|
dc.contributor.author |
Bohács Anikó |
|
dc.contributor.author |
Losonczy György |
|
dc.contributor.author |
Rigó János |
|
dc.contributor.author |
Horváth Ildikó |
|
dc.contributor.author |
Tamási Lilla |
|
dc.date.accessioned |
2015-07-01T08:31:07Z |
|
dc.date.available |
2015-07-01T08:31:07Z |
|
dc.date.issued |
2014 |
|
dc.identifier |
84910097186 |
|
dc.identifier.citation |
pagination=93;
journalVolume=12;
journalIssueNumber=1;
journalTitle=REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/1917 |
|
dc.identifier.uri |
doi:10.1186/1477-7827-12-93 |
|
dc.description.abstract |
BACKGROUND: Asthma is one of the most common conditions which complicate pregnancy. Pro- and anti-apoptotic mechanisms can be modulated by asthma accompanying pregnancy. Survivin, an anti-apoptotic protein has been implicated in the pathomechanism of asthma and also in the development of pathological pregnancies; however survivin has not been studied in pregnant asthmatics. METHODS: Twenty-eight asthmatic pregnant (AP), 25 asthmatic non-pregnant (ANP), 21 healthy pregnant (HP) and 29 healthy non-pregnant (HNP) women were enrolled in this cross-sectional study. Plasma survivin concentration was determined by ELISA. RESULTS: Plasma survivin was significantly lower in HP (1.64 /0-74.9/ pg/ml) than in HNP (24.6 /0-333.3/ pg/ml, p = 0.01). However, this difference was not observed between the asthmatic groups (p = 0.64). Similarly, there was no difference either between HNP and ANP (10.5 /0-215.4/ pg/ml, p = 0.23) or between HP and AP (13.9 /0-364.1/ pg/ml, p = 0.30) groups. CONCLUSIONS: Decreased plasma survivin levels in physiological but not in asthmatic pregnancy may suggest that the normal apoptotic mechanisms are compromised in asthmatic gestation. |
|
dc.relation.ispartof |
urn:issn:1477-7827 |
|
dc.title |
Circulating survivin levels in healthy and asthmatic pregnancy. |
|
dc.type |
Journal Article |
|
dc.date.updated |
2015-07-01T08:30:27Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
2741489 |
|
dc.identifier.wos |
WOS:000344115400002 |
|
dc.identifier.pubmed |
25248821 |
|
dc.contributor.department |
SE/AOK/K/I. Sz. Szülészeti és Nőgyógyászati Klinika |
|
dc.contributor.department |
SE/AOK/K/Pulmonológiai Klinika |
|
dc.contributor.institution |
Semmelweis Egyetem |
|