dc.contributor.author |
Gonda, Xénia |
|
dc.contributor.author |
Fountoulakis KN, |
|
dc.contributor.author |
Csukly, Gábor |
|
dc.contributor.author |
Döme, Péter |
|
dc.contributor.author |
Sarchiapone M, |
|
dc.contributor.author |
Lászik, András |
|
dc.contributor.author |
Juhász, Gabriella |
|
dc.contributor.author |
Rudisch, Tibor |
|
dc.contributor.author |
Molnár, Eszter |
|
dc.contributor.author |
Pap, Dorottya |
|
dc.contributor.author |
Bagdy, György |
|
dc.contributor.author |
Rihmer, Zoltán |
|
dc.date.accessioned |
2015-10-26T19:48:32Z |
|
dc.date.available |
2015-10-26T19:48:32Z |
|
dc.date.issued |
2012 |
|
dc.identifier |
84869498691 |
|
dc.identifier.citation |
pagination=75-83;
journalVolume=143;
journalIssueNumber=1-3;
journalTitle=JOURNAL OF AFFECTIVE DISORDERS; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/1999 |
|
dc.identifier.uri |
doi:10.1016/j.jad.2012.05.031 |
|
dc.description.abstract |
BACKGROUND:
Birth season has well-known effects on neuropsychiatric
disorders, and may also influence genotype distribution by
possibly influencing chance of conception via parental
idiosyncratic conception patterns or survival of foetuses or
infants. The 5-HTTLPR is associated with phenomena including
affective temperaments or suicide which are also associated with
birth season. Our aim was to investigate the association of 5-
HTTLPR genotype and birth season in a healthy female population.
METHODS:
Birth date and 5-HTTLPR genotype was determined for 327
psychiatrically healthy women. The association between presence
of s allele and time of birth was analysed using generalized
linear models.
RESULTS:
A significant association between s allele frequency and time of
birth was detected. S allele carrier frequency was marginally
significantly higher in July borns and significantly lower in
autumn borns.
LIMITATIONS:
We investigated an adult sample so genotype frequency data do
not reflect birth frequencies. Our sample consisted exclusively
of females.
CONCLUSIONS:
There is no clear explanation for the observed association,
although idiosyncratic parental conception patterns, the
association of 5-HTTLPR with sudden infant/intrauterine death,
or other s allele-mediated behaviours may play a role. Our
results are strikingly parallel with earlier data reporting a
higher risk of completed suicide in July borns, and higher
scores of July borns and lower scores of autumn borns on certain
affective temperament scales, both of which are also associated
with the s allele of 5-HTTLPR. Thus our results may add to the
growing body of evidence regarding the etiological background of
affective disorders. |
|
dc.relation.ispartof |
urn:issn:0165-0327 |
|
dc.title |
Star-crossed? The association of the 5-HTTLPR s allele with season of birth in a healthy female population, and possible consequences for temperament, depression and suicide |
|
dc.type |
Journal Article |
|
dc.date.updated |
2015-07-09T09:36:00Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
2063663 |
|
dc.identifier.wos |
000311213800011 |
|
dc.identifier.pubmed |
22840619 |
|
dc.contributor.department |
SE/GYTK/Gyógyszerhatástani Intézet |
|
dc.contributor.department |
SE/KSZE/Kútvölgyi Klinikai Tömb Klinikai és Kutatási Mentálhigiénés Osztály |
|
dc.contributor.institution |
Semmelweis Egyetem |
|