Show simple item record Lauria A, Barker A, Schloot N, Hosszúfalusi, Nóra Ludvigsson J, Mathieu C Mauricio D Nordwall M Van der Schueren B Mandrup-Poulsen T Scherbaum WA Weets I Gorus FK Wareham N Leslie RD Pozzilli P 2016-08-25T12:45:38Z 2016-08-25T12:45:38Z 2015
dc.identifier.citation pagination=107-113; journalVolume=172; journalIssueNumber=2; journalTitle=EUROPEAN JOURNAL OF ENDOCRINOLOGY;
dc.identifier.uri doi:10.1530/EJE-14-0522
dc.description.abstract OBJECTIVE: Body weight-related insulin resistance probably plays a role in progression to type 1 diabetes, but has an uncertain impact following diagnosis. In this study, we investigated whether BMI measured at diagnosis was an independent predictor of C-peptide decline 1-year post-diagnosis. DESIGN: Multicentre longitudinal study carried out at diagnosis and up to 1-year follow-up. METHODS: Data on C-peptide were collected from seven diabetes centres in Europe. Patients were grouped according to age at diagnosis (<5 years, n=126; >5 years <10 years, n=295; >10 years <18 years, n=421; >18 years, n=410). Linear regression was used to investigate whether BMI was an independent predictor of change in fasting C-peptide over 1 year. Models were additionally adjusted for baseline insulin dose and HbA1c. RESULTS: In individuals diagnosed between 0 and 5 years, 5 and 10 years and those diagnosed >18 years, we found no association between BMI and C-peptide decline. In patients aged 10-18 years, higher BMI at baseline was associated with a greater decline in fasting C-peptide over 1 year with a decrease (beta 95% CI; P value) of 0.025 (0.010, 0.041) nM/kg per m(2) higher baseline BMI (P=0.001). This association remained significant after adjusting for gender and differences in HbA1c and insulin dose (beta=0.026, 95% CI=0.0097, 0.042; P=0.002). CONCLUSIONS: These observations indicate that increased body weight and increased insulin demand are associated with more rapid disease progression after diagnosis of type 1 diabetes in an age group 10-18 years. This should be considered in studies of beta-cell function in type 1 diabetes.
dc.relation.ispartof urn:issn:0804-4643
dc.title BMI is an important driver of beta-cell loss in type 1 diabetes upon diagnosis in 10 to 18-year-old children.
dc.type Journal Article 2015-07-28T08:46:38Z
dc.language.rfc3066 en
dc.identifier.mtmt 2880264
dc.identifier.wos 000349458000007
dc.identifier.pubmed 25378371
dc.contributor.department SE/AOK/K/III. Sz. Belgyógyászati Klinika
dc.contributor.institution Semmelweis Egyetem
dc.mtmt.swordnote Hiányzó Besorolás: 'Journal Article\n\nMulticenter Study\n\nResearch Support, Non-U.S. Gov\'t',24

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