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dc.contributor.author Bánfi, Gergely
dc.contributor.author Teleki, Ivett
dc.contributor.author Nyirády, Péter
dc.contributor.author Keszthelyi, Attila
dc.contributor.author Romics, Imre
dc.contributor.author Fintha, Attila
dc.contributor.author Krenács, Tibor
dc.contributor.author Szende, Béla
dc.date.accessioned 2015-09-09T13:02:03Z
dc.date.available 2015-09-09T13:02:03Z
dc.date.issued 2015
dc.identifier 84929104184
dc.identifier.citation pagination=1149-1154; journalVolume=47; journalIssueNumber=7; journalTitle=INTERNATIONAL UROLOGY AND NEPHROLOGY;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/2142
dc.identifier.uri doi:10.1007/s11255-015-0985-1
dc.description.abstract OBJECTIVE: The majority of prostate cancers require androgen hormones for growth, and androgen ablation is an important part of the systemic treatment of advanced prostate cancer. Nevertheless, most of these cancers eventually relapse as they become less sensitive to androgen ablation and anti-androgen treatment. Elucidating the molecular events that are responsible for the conversion of androgen-sensitive cancers to androgen-refractory tumors may reveal new therapeutic opportunities. METHODS: In the present study, we investigated nine androgen-sensitive and nine androgen-refractory prostate cancer samples to evaluate the expression levels of 10 selected proteins that have been implicated in oncogenesis and cancer progression. RESULTS: Our immunohistochemical data show that three of the investigated proteins (i.e., minichromosome maintenance-2, methylguanine-DNA methyltransferase, and androgen receptor) are expressed at significantly different levels in the androgen-refractory cancer samples than in the androgen-sensitive tumors, whereas the expression levels of the seven other studied proteins (i.e., beta-catenin, p27, p21, p16, Ki67, hypoxia-inducible factor 1 alpha, and geminin) are not significantly different regarding the two groups. CONCLUSIONS: Our data suggest that the increased expression of minichromosome maintenance-2 and decreased expression of methylguanine-DNA methyltransferase related to androgen receptor are indicative of the androgen-refractory stage in prostate cancer. Further studies are required to determine whether these expression changes play a causative role in the transition of androgen-sensitive to androgen-refractory prostate cancer.
dc.relation.ispartof urn:issn:0301-1623
dc.title Changes of protein expression in prostate cancer having lost its androgen sensitivity.
dc.type Journal Article
dc.date.updated 2015-08-28T07:12:28Z
dc.language.rfc3066 en
dc.identifier.mtmt 2891839
dc.identifier.wos 000356902100016
dc.identifier.pubmed 25953123
dc.contributor.department SE/AOK/I/I. Sz. Patológiai és Kísérleti Rákkutató Intézet
dc.contributor.department SE/AOK/I/II. Sz. Patológiai Intézet
dc.contributor.department SE/AOK/K/Urológiai Klinika
dc.contributor.institution Semmelweis Egyetem
dc.mtmt.swordnote published online 2015 May


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