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dc.contributor.author Pápay, Zsófia Edit
dc.contributor.author Sebestyén, Zita
dc.contributor.author Ludányi, Krisztina
dc.contributor.author Kállai-Szabó, Nikolett
dc.contributor.author Bertalanné Balogh, Emese
dc.contributor.author Antal, István
dc.date.accessioned 2015-09-17T15:37:59Z
dc.date.available 2015-09-17T15:37:59Z
dc.date.issued 2016
dc.identifier.citation pagination=210-216; journalVolume=117; journalTitle=JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/2175
dc.identifier.uri doi:10.1016/j.jpba.2015.08.019
dc.description.abstract Abstract The aqueous solubility of a flavonoid, apigenin, was studied in the presence of first generation cyclodextrins (α-CyD, β-CyD, γ-CyD), ionic and nonionic synthetic derivatives of β-CyD, namely SBE-β-CyD, HP-β-CyD and RM-β-CyD at various physiological pH. The order of solubility enhancement was as follows: RM-β-CyD > SBE-β-CyD > γ-CyD > HP-β-CyD > β-CyD > α-CyD. The phase solubility diagrams of HP-β-CyD and SBE-β-CyD indicated Higuchi AL subtype behavior, suggesting 1:1 stoichiometry of the complex. In contrast, AP subtype, so higher order complex formation can be assumed in the case of RM-β-CyD and γ-CyD. The formation of inclusion complexes has been confirmed by absorption and fluorescence spectroscopic measurements. Increased antioxidant activity was observed due to the inclusion complexes. These results prove that synthetic derivatives of β-CyD will be potentially useful excipients in the development of drug delivery systems for healthcare products containing flavonoids.
dc.relation.ispartof urn:issn:0731-7085
dc.title Comparative evaluation of the effect of cyclodextrins and pH on aqueous solubility of apigenin
dc.type Journal Article
dc.date.updated 2015-09-17T15:37:15Z
dc.language.rfc3066 en
dc.identifier.mtmt 2942763
dc.identifier.pubmed 26363816
dc.contributor.department SE/GYTK/Gyógyszerészeti Intézet
dc.contributor.institution Semmelweis Egyetem


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