Show simple item record Kutszegi, Nóra Semsei, Ágnes F Gézsi, András C. Sági, Judit Nagy V Csordas, Katalin Jakab, Zsuzsanna Lautner-Csorba, Orsolya Gabor KM Kovács, Gábor Erdélyi, Dániel Szalai, Csaba 2016-06-21T09:33:59Z 2016-06-21T09:33:59Z 2015
dc.identifier.citation pagination=e0140136; journalVolume=10; journalIssueNumber=10; journalTitle=PLOS ONE;
dc.identifier.uri doi:10.1371/journal.pone.0140136
dc.description.abstract L-asparaginase (ASP) is a key element in the treatment of paediatric acute lymphoblastic leukaemia (ALL). However, hypersensitivity reactions (HSRs) to ASP are major challenges in paediatric patients. Our aim was to investigate genetic variants that may influence the risk to Escherichia coli-derived ASP hypersensitivity. Sample and clinical data collection was carried out from 576 paediatric ALL patients who were treated according to protocols from the Berlin-Frankfurt-Munster Study Group. A total of 20 single nucleotide polymorphisms (SNPs) in GRIA1 and GALNT10 genes were genotyped. Patients with GRIA1 rs4958351 AA/AG genotype showed significantly reduced risk to ASP hypersensitivity compared to patients with GG genotype in the T-cell ALL subgroup (OR = 0.05 (0.01-0.26); p = 4.70E-04), while no such association was found in pre-B-cell ALL. In the medium risk group two SNPs of GRIA1 (rs2055083 and rs707176) were associated significantly with the occurrence of ASP hypersensitivity (OR = 0.21 (0.09-0.53); p = 8.48E-04 and OR = 3.02 (1.36-6.73); p = 6.76E-03, respectively). Evaluating the genders separately, however, the association of rs707176 with ASP HSRs was confined only to females. Our results suggest that genetic variants of GRIA1 might influence the risk to ASP hypersensitivity, but subgroups of patients can differ significantly in this respect.
dc.relation.ispartof urn:issn:1932-6203
dc.title Subgroups of Paediatric Acute Lymphoblastic Leukaemia Might Differ Significantly in Genetic Predisposition to Asparaginase Hypersensitivity.
dc.type Journal Article 2015-10-28T08:08:28Z
dc.language.rfc3066 en
dc.identifier.mtmt 2961156
dc.identifier.pubmed 26457809
dc.contributor.department SE/AOK/K/II. Sz. Gyermekgyógyászati Klinika
dc.contributor.department SE/AOK/I/Genetikai, Sejt- és Immunbiológiai Intézet
dc.contributor.institution Semmelweis Egyetem
dc.mtmt.swordnote PMC PMC4601692

Files in this item



This item appears in the following Collection(s)

Show simple item record

Search DSpace

Advanced Search


My Account