dc.contributor.author |
Bárdi, Edit |
|
dc.contributor.author |
Csóka, Monika |
|
dc.contributor.author |
Garai, Ildikó |
|
dc.contributor.author |
Szegedi, István |
|
dc.contributor.author |
Müller, Judit |
|
dc.contributor.author |
Györke, Tamás |
|
dc.contributor.author |
Kajáry, Kornélia |
|
dc.contributor.author |
Nemes, Karolina |
|
dc.contributor.author |
Kiss, Csongor |
|
dc.contributor.author |
Kovács, Gábor |
|
dc.date.accessioned |
2016-09-14T14:10:09Z |
|
dc.date.available |
2016-09-14T14:10:09Z |
|
dc.date.issued |
2014 |
|
dc.identifier |
84896034980 |
|
dc.identifier.citation |
pagination=139-143;
journalVolume=20;
journalIssueNumber=1;
journalTitle=PATHOLOGY AND ONCOLOGY RESEARCH; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/2282 |
|
dc.identifier.uri |
doi:10.1007/s12253-013-9676-3 |
|
dc.description.abstract |
The aim of the study was to assess sensitivity and specificity of FDG-PET/CT in different forms of childhood cancer. We retrospectively evaluated the results dedicated of 162 FDG-PET/CT examinations of 86 children treated with: Hodgkin lymphoma (HL; n = 31), non-Hodgkin lymphoma (NHL; n = 30) and other high grade solid tumors (n = 25). Patients were admitted and treated in two departments of pediatric hematology and oncology in Hungary. FDG-PET/CT was performed for staging (n = 25) and for posttreatment evaluation (n = 137). Imaging was performed in three FDG-PET/CT Laboratories, using dedicated PET/CT scanners. False positive results were defined as resolution or absence of disease progression over at least 1 year on FDG-PET/CT scans without any intervention. In some cases histopathological evaluation of suspicious lesions was performed. Fals negative results were defined as negative FDG-PET/CT results in case of active malignancy. Positive predictive values (PPV) and negative predictive values (NPV) were calculated. NPV was 100 %. The highest PPV was observed in high grade solid tumors (81 %), followed by HL (65 %) and NHL (61 %). There was a major difference of PPV in different histological types of HL (50 % in HL of mixed-cellularity subtype, 90 % in nodular sclerosing, and 100 % in lymphocyte-rich and lymphocyte depleted HL). We treated one patient with nodular lymphocyte predominant HL, who had 5 false positive FDG-PET/CT results. PPV of T- and B-lineage NHL were similar (60 % and 62 %, respectively). We observed an interesting difference of PPV in different stages of HL and NHL. In HL PPV was higher in early than in advanced disease forms: 66 % in stage II HL and 60 % in stage III HL, whereas there was an inverse relationship between PPV and disease stages in NHL 0 % in stage I and II patients, 67 % in stage III and 100 % in stage IV patients. PPV was lower in males (54 %) than in females (65 %). PPV were 64 % vs. 58 % in patients under vs. over 10 years of age. Negative FDG-PET/CT results during follow-up reliably predict the absence of malignancy. Positive FDG-PET/CT scan results in general have a low PPV. The relatively high PPV in patients with histologically proven high grade solid tumors, advanced stages of NHL and with nodular sclerosing, lymphocyte-rich and lymphocyte depleted subtypes of HL warrant a confirmation by biopsy, whereas the watch-and-wait approach can be used in other forms of childhood cancer patients with a positive FDG-PET/CT result in course of follow-up examinations. |
|
dc.relation.ispartof |
urn:issn:1219-4956 |
|
dc.title |
Value of FDG-PET/CT Examinations in Different Cancers of Children, Focusing on Lymphomas |
|
dc.type |
Journal Article |
|
dc.date.updated |
2015-11-06T12:56:37Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
2391726 |
|
dc.identifier.wos |
000329356600017 |
|
dc.identifier.pubmed |
23955198 |
|
dc.contributor.department |
SE/AOK/K/II. Sz. Gyermekgyógyászati Klinika |
|
dc.contributor.department |
SE/AOK/K/Nukleáris Medicia Tanszék |
|
dc.contributor.institution |
Semmelweis Egyetem |
|