Show simple item record Faust K Hartel C Preuss M Rabe H Roll C Emeis M Wieg C Szabó, Miklós Herting E Gopel W Neocirculation project and the German Neonatal Network (GNN) 2016-09-27T09:42:18Z 2016-09-27T09:42:18Z 2015
dc.identifier.citation pagination=F388-F392;journalVolume=100;journalIssueNumber=5;journalTitle=ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION; hu
dc.identifier.uri doi:10.1136/archdischild-2014-306483
dc.description.abstract OBJECTIVE: To evaluate lowest mean arterial blood pressure during the first 24 h of life (minMAP(24)) in very-low-birthweight (VLBW) infants and to identify associations between hypotension and short-term outcome. DESIGN: Retrospective cohort analysis of the minMAP(24) of 4907 VLBW infants with a gestational age <32 weeks in correlation with clinical data. Hypotension was defined as minMAP(24) being lower than the median value of all patients of the same gestational age. RESULTS: MinMAP(24) values correlated with gestational age. Median minMAP(24) values of VLBW infants </=29 weeks' gestation were 1-2 mm Hg lower than gestational age in completed weeks. Hypotensive infants had a higher rate of intraventricular haemorrhage (IVH, 20.3% vs 15.9%, p<0.001), bronchopulmonary dysplasia (BPD, 19.2% vs 15.1%, p<0.001) and death (5.2% vs 3.0%, p<0.001). Multivariate logistic regression analyses, including potential confounders, confirmed these data. MinMAP(24) was an independent risk factor for IVH (OR 0.97/mm Hg, 95% CI 0.96 to 0.99, p=0.003), BPD (OR 0.96/mm Hg, 95% CI 0.94 to 0.98, p<0.001) and mortality (OR 0.94/mm Hg, 95% CI 0.90 to 0.98, p=0.003). CONCLUSIONS: Hypotension during the first 24 h of life is associated with adverse outcomes in VLBW infants. This underlines the need for randomised controlled trials on the use of vasoactive drugs in this vulnerable patient cohort. hu
dc.relation.ispartof urn:issn:1359-2998
dc.title Short-term outcome of very-low-birthweight infants with arterial hypotension in the first 24 h of life hu
dc.type Journal Article hu 2015-11-09T10:47:50Z
dc.language.rfc3066 en hu
dc.identifier.mtmt 2952334
dc.identifier.wos 000360470000005
dc.identifier.pubmed 26199082
dc.contributor.institution Semmelweis Egyetem
dc.mtmt.swordnote CN Neocirculation project and the German Neonatal Network (GNN)

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