Show simple item record Laszlo A, Babos L, Kis-Igari Z, Palfy A, Torzsa, Péter Eőry, Ajándék Kalabay, László Gonda, Xénia Rihmer, Zoltán Cseprekál, Orsolya Tislér, András Hodrea, Judit Lénárt, Lilla Fekete, Andrea Nemcsik, János 2016-01-17T12:53:06Z 2016-01-17T12:53:06Z 2015
dc.identifier.citation pagination=33; journalVolume=14; journalTitle=ANNALS OF GENERAL PSYCHIATRY;
dc.identifier.uri doi:10.1186/s12991-015-0072-0
dc.description.abstract BACKGROUND: Although mood disorders and cardiovascular diseases have widely studied psychosomatic connections, data concerning the influence of the psychopathologically important affective temperaments in hypertension are scarce. To define a possibly higher cardiovascular risk subpopulation we investigated in well-treated hypertensive patients with dominant affective temperaments (DOM) and in well-treated hypertensive patients without dominant temperaments the level of depression and anxiety, arterial stiffness and serum Brain-derived Neurotrophic Factor (seBDNF). METHODS: 175 hypertensive patients, free of the history of psychiatric diseases, completed the TEMPS-A, Beck Depression Inventory and Hamilton Anxiety Scale questionnaires in two primary care practices. Of those 175 patients, 24 DOM patients and 24 hypertensive controls (matched in age, sex and the presence of diabetes) were selected for measurements of arterial stiffness and seBDNF level. RESULTS: Beck and Hamilton scores in DOM patients were higher compared with controls. Pulse wave velocity and augmentation index did not differ between the groups while in the DOM patients decreased brachial systolic and diastolic and central diastolic blood pressures were found compared with controls. SeBDNF was lower in the DOM group than in the controls (22.4 +/- 7.2 vs. 27.3 +/- 7.8 ng/mL, p < 0.05). CONCLUSIONS: Although similar arterial stiffness parameters were found in DOM patients, their increased depression and anxiety scores, the decreased brachial and central diastolic blood pressures as well as the decreased seBDNF might refer to their higher vulnerability regarding the development not only of major mood disorders, but also of cardiovascular complications. These data suggest that the evaluation of affective temperaments should get more attention both with regard to psychopathology and cardiovascular health management.
dc.relation.ispartof urn:issn:1744-859X
dc.title Identification of hypertensive patients with dominant affective temperaments might improve the psychopathological and cardiovascular risk stratification: a pilot, case-control study.
dc.type Journal Article 2015-11-20T11:19:19Z
dc.language.rfc3066 en
dc.identifier.mtmt 2962725
dc.identifier.pubmed 26512294
dc.contributor.department SE/AOK/K/Családorvosi Tanszék
dc.contributor.department SE/GYTK/Gyógyszerhatástani Intézet
dc.contributor.department SE/AOK/I/Kútvölgyi Klinikai Tömb Klinikai és Kutatási Mentálhigiénés Osztály
dc.contributor.department SE/AOK/K/I. Sz. Belgyógyászati Klinika
dc.contributor.department SE/AOK/K/ISZGYK/MTA-SE Lendület Diabétesz Kutatócsoport
dc.contributor.department SE/GYTK/GYHATAS/MTA-SE Neuropszichofarmakológiai és Neurokémiai Kutatócsoport
dc.contributor.institution Semmelweis Egyetem

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