Intestinal dysbiosis is linked to numerous gastrointestinal disorders, including inflammatory bowel diseases. It is a question of debate if coxibs, selective inhibitors of cyclooxygenase (COX)-2, cause dysbiosis. Therefore, ...

Little is known about the molecular mechanism including microRNAs (miRNA) in hypercholesterolemia-induced cardiac dysfunction. We aimed to explore novel hypercholesterolemia-induced pathway alterations in the heart by an ...

Growing data support the peripheral opioid antinociceptive effect, particularly, in inflammatory pain models. Here, we examined the antinociceptive effects of the subcutaneously (s.c.) administered, recently synthesized ...

During ischemia/reperfusion (IR), increased activation of angiotensin AT1 receptors recruits NADPH oxidase 2 (NOX2) which contributes to oxidative stress. It is unknown whether this stimulus can induce oxidative activation ...

Despite the great clinical significance of radiation-induced cardiac damage, experimental investigation of its mechanisms is an unmet need in medicine. Beneficial effects of growth hormone-releasing hormone (GHRH) agonists ...

BACKGROUND AND PURPOSE: Incidence and severity of obesity is increasing worldwide. To date, efficient and safe pharmacological tools to treat or prevent obesity have not been developed. Certain monoamine-oxidase (MAO) ...

Microglia are highly dynamic cells in the brain. Their functional diversity and phenotypic versatility brought microglial energy metabolism into the focus of research. Although it is known that microenvironmental cues shape ...