dc.contributor.author |
Széplaki, Gábor |
|
dc.contributor.author |
Varga, Lilian |
|
dc.contributor.author |
Laki J |
|
dc.contributor.author |
Dósa, Edit |
|
dc.contributor.author |
Rugonfalvi-Kiss S |
|
dc.contributor.author |
Madsen HO |
|
dc.contributor.author |
Prohászka, Zoltán |
|
dc.contributor.author |
Kocsis, Andrea |
|
dc.contributor.author |
Gál, Péter |
|
dc.contributor.author |
Szabó, Attila |
|
dc.contributor.author |
Acsády, György |
|
dc.contributor.author |
Karádi, István |
|
dc.contributor.author |
Selmeci L |
|
dc.contributor.author |
Garred P |
|
dc.contributor.author |
Füst, György |
|
dc.contributor.author |
Entz, László |
|
dc.date.accessioned |
2016-04-10T12:56:17Z |
|
dc.date.available |
2016-04-10T12:56:17Z |
|
dc.date.issued |
2007 |
|
dc.identifier |
36348991407 |
|
dc.identifier.citation |
pagination=2756-2762;
journalVolume=27;
journalIssueNumber=12;
journalTitle=ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/2627 |
|
dc.identifier.uri |
doi:10.1161/ATVBAHA.107.146860 |
|
dc.description.abstract |
OBJECTIVE: Homozygotes for the normal (A) allele of mannose-binding lectin (MBL2) gene have higher risks to develop an early restenosis after eversion carotid endarterectomy (CEA). Activation of the lectin pathway is regulated by C1-inhibitor (C1-INH). The objective of the present study was to determine the predictive value of C1-INH in restenosis after CEA. METHODS AND RESULTS: C1-INH and MBL-associated serine protease-2 (MASP-2) were determined in samples serially taken from 64 patients with CEA, who were followed-up with carotid duplex scan (CDS) examinations for 14 months. MBL2 genotypes were also determined. Patients with >50% restenosis had lower C1-INH levels at 6 weeks (P=0.0052) and at 4 days (P=0.0277) postsurgery. C1-INH levels at 6 weeks correlated inversely with the CDS values at 14 months (r=-0.3415, P=0.0058), but only in MBL2 A/A homozygotes (r=-0.5044, P=0.0015). Patients with low C1-INH levels (C1-INH <115%) had higher CDS values already at 7 months postsurgery. Patients with MBL2 A/A and low C1-INH levels at 6 weeks postsurgery had 13.97 (95% CI:1.95 to 100.21, P=0.0087) times higher risk to develop an early restenosis. Differences in the MASP-2 concentration were not associated with restenosis. CONCLUSIONS: Determining C1-INH levels at 6 weeks postsurgery-together with genotyping of MBL2-might be a useful marker in the identification of patients with high risk for early carotid restenosis. |
|
dc.relation.ispartof |
urn:issn:1079-5642 |
|
dc.title |
Low c1-inhibitor levels predict early restenosis after eversion carotidendarterectomy. |
|
dc.type |
Journal Article |
|
dc.date.updated |
2015-11-24T10:42:46Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
1297177 |
|
dc.identifier.wos |
000251143300041 |
|
dc.identifier.pubmed |
17916775 |
|
dc.contributor.department |
SE/AOK/K/III. Sz. Belgyógyászati Klinika |
|
dc.contributor.department |
SE/AOK/K/Érsebészeti Klinika [2011.12.31] |
|
dc.contributor.department |
MTA TKI/MTA-SE Gyulladásbiológiai és Immungenomikai Kutatócsoport (2006-ig: MTA-SE Molekuláris Immunológiai Kutatócsoport) |
|
dc.contributor.institution |
Semmelweis Egyetem |
|