Peroxidasins: novel players in tissue genesis

dc.contributor.author	Péterfi, Zalán
dc.contributor.author	Geiszt, Miklós
dc.date.accessioned	2016-09-13T08:55:00Z
dc.date.available	2016-09-13T08:55:00Z
dc.date.issued	2014
dc.identifier	84901738565
dc.identifier.citation	pagination=305-307; journalVolume=39; journalIssueNumber=7; journalTitle=TRENDS IN BIOCHEMICAL SCIENCES;
dc.identifier.uri	http://repo.lib.semmelweis.hu//handle/123456789/2660
dc.identifier.uri	doi:10.1016/j.tibs.2014.05.005
dc.description.abstract	Stabilization of extracellular matrix by protein crosslinking is a universal and essential process in multicellular organisms. Recent findings revealed that peroxidasin, a unique heme-peroxidase, produces hypohalides to support matrix synthesis. Unexpectedly, the highly reactive and potentially damaging hypohalides mediate the formation of sulfilimine bonds between adjacent collagen IV protomers. This crosslink is a fundamental feature of basal membranes, defining peroxidasin-dependent oxidant generation and sulfilimine crosslink formation as an elemental mechanism of tissue biogenesis. © 2014 Elsevier Ltd. All rights reserved.
dc.relation.ispartof	urn:issn:0968-0004
dc.title	Peroxidasins: novel players in tissue genesis
dc.type	Journal Article
dc.date.updated	2015-11-24T14:08:10Z
dc.language.rfc3066	en
dc.identifier.mtmt	2706633
dc.identifier.wos	000338915800002
dc.contributor.department	Semmelweis Egyetem
dc.contributor.department	SE/AOK/I/Élettani Intézet
dc.contributor.department	SE/AOK/I/ÉI/MTA-SE Lendület Peroxidáz Enzimek Kutatócsoport