dc.contributor.author |
Péterfi, Zalán |
|
dc.contributor.author |
Geiszt, Miklós |
|
dc.date.accessioned |
2016-09-13T08:55:00Z |
|
dc.date.available |
2016-09-13T08:55:00Z |
|
dc.date.issued |
2014 |
|
dc.identifier |
84901738565 |
|
dc.identifier.citation |
pagination=305-307;
journalVolume=39;
journalIssueNumber=7;
journalTitle=TRENDS IN BIOCHEMICAL SCIENCES; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/2660 |
|
dc.identifier.uri |
doi:10.1016/j.tibs.2014.05.005 |
|
dc.description.abstract |
Stabilization of extracellular matrix by protein crosslinking is a universal and essential process in multicellular organisms. Recent findings revealed that peroxidasin, a unique heme-peroxidase, produces hypohalides to support matrix synthesis. Unexpectedly, the highly reactive and potentially damaging hypohalides mediate the formation of sulfilimine bonds between adjacent collagen IV protomers. This crosslink is a fundamental feature of basal membranes, defining peroxidasin-dependent oxidant generation and sulfilimine crosslink formation as an elemental mechanism of tissue biogenesis. © 2014 Elsevier Ltd. All rights reserved. |
|
dc.relation.ispartof |
urn:issn:0968-0004 |
|
dc.title |
Peroxidasins: novel players in tissue genesis |
|
dc.type |
Journal Article |
|
dc.date.updated |
2015-11-24T14:08:10Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
2706633 |
|
dc.identifier.wos |
000338915800002 |
|
dc.contributor.department |
Semmelweis Egyetem |
|
dc.contributor.department |
SE/AOK/I/Élettani Intézet |
|
dc.contributor.department |
SE/AOK/I/ÉI/MTA-SE Lendület Peroxidáz Enzimek Kutatócsoport |
|