dc.contributor.author |
Keszler, Gergely |
|
dc.contributor.author |
Kruk E |
|
dc.contributor.author |
Kenézlői, Eszter |
|
dc.contributor.author |
Tarnok Z |
|
dc.contributor.author |
Sasvári-Székely, Mária |
|
dc.contributor.author |
Nemoda, Zsófia |
|
dc.date.accessioned |
2016-07-13T07:37:07Z |
|
dc.date.available |
2016-07-13T07:37:07Z |
|
dc.date.issued |
2014 |
|
dc.identifier |
84910650713 |
|
dc.identifier.citation |
pagination=493-498;
journalVolume=41;
journalIssueNumber=6;
journalTitle=INTERNATIONAL JOURNAL OF IMMUNOGENETICS; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/2725 |
|
dc.identifier.uri |
doi:10.1111/iji.12147 |
|
dc.description.abstract |
Several lines of evidence suggest that certain subtypes of obsessive-compulsive and tic disorders might be paediatric manifestations of post-streptococcal autoimmunity caused by cross-reactive autoantibodies. As tumor necrosis factor (TNF) is known to play a seminal role in coordinating the humoral immune response, TNF gene polymorphisms have been proposed as genetic risk factors both in obsessive-compulsive disorder (OCD) and Tourette syndrome (TS). The aim of this study was to investigate two TNF promoter polymorphisms (-238 A/G: rs361525 and -308 A/G: rs1800629) on the genetic susceptibility to OCD and TS in a child psychiatric sample (102 patients with OCD and 117 patients with TS). In the case-control set-up, the genotype and allele frequencies were compared to a control group from the general population (n = 405). As a control child psychiatric sample, 194 children with attention-deficit hyperactivity disorder were also genotyped. Our results revealed that the TNF -308 G-allele was more frequent in children with TS compared to controls (90.2% vs 84.8%, P = 0.037). For confirmation of this genetic association, a family-based analysis, the transmission disequilibrium test was used, which showed preferential transmission of the G-allele to patients with TS (nominal P-value 0.011). Moreover, this allele was also transmitted more frequently to children with tic symptoms (nominal P-value 0.039). No association was found between OCD or obsessive-compulsive symptoms and the studied TNF polymorphisms. Based on these findings, the TNF -308 G-allele can be associated with Tourette syndrome, highlighting the potential pathophysiological role of TNF dysregulation. |
|
dc.relation.ispartof |
urn:issn:1744-3121 |
|
dc.title |
Association of the tumor necrosis factor -308 A/G promoter polymorphism with Tourette syndrome |
|
dc.type |
Journal Article |
|
dc.date.updated |
2015-11-25T10:45:41Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
2802995 |
|
dc.identifier.wos |
000345297600007 |
|
dc.identifier.scopus |
84910650713 |
|
dc.identifier.pubmed |
25256363 |
|
dc.contributor.department |
SE/AOK/I/Orvosi Vegytani, Molekuláris Biológiai és Patobiokémiai Intézet |
|
dc.contributor.institution |
Semmelweis Egyetem |
|