dc.contributor.author |
Literáti-Nagy, Zsuzsanna |
|
dc.contributor.author |
Tory K |
|
dc.contributor.author |
Literáti-Nagy, Botond |
|
dc.contributor.author |
Bajza A |
|
dc.contributor.author |
Vígh, László Jr. |
|
dc.contributor.author |
Vigh, László |
|
dc.contributor.author |
Mandl, József |
|
dc.contributor.author |
Szilvássy, Zoltán |
|
dc.date.accessioned |
2017-01-05T15:29:55Z |
|
dc.date.available |
2017-01-05T15:29:55Z |
|
dc.date.issued |
2013 |
|
dc.identifier.citation |
pagination=571-575;
journalVolume=19;
journalIssueNumber=3;
journalTitle=PATHOLOGY AND ONCOLOGY RESEARCH; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/2752 |
|
dc.identifier.uri |
doi:10.1007/s12253-013-9620-6 |
|
dc.description.abstract |
Abdominal obesity is referred for as a common pathogenic root of
multiple risk factors, which include insulin resistance,
dyslipidemia, hypertension, and a pro-atherogenic and pro-
inflammatory state. Irrespective of its psychiatric side
effects, rimonabant through blocking cannabinoid-1 receptor
(CB1R) induces an increase in whole body insulin sensitivity.
The aim of this work was to study the effect of selected doses
of another insulin sensitizer compound BGP-15, and rimonabant on
insulin resistance in Zucker obese rats with a promise of
inducing insulin sensitization together at lower doses than
would have been expected by rimonabant alone. We found that BGP-
15 potentiates the insulin sensitizing effect of rimonabant. The
combination at doses, which do not induce insulin sensitization
by themselves, improved insulin signaling. Furthermore our
results suggest that capsaicin-induced signal may play a role in
insulin sensitizing effect of both molecules. Our data might
indicate that a lower dose of rimonabant in the treatment of
insulin resistance and type 2 diabetes is sufficient to
administer, thus a lower incidence of the unfavorable
psychiatric side effects of rimonabant are to be expected. |
|
dc.relation.ispartof |
urn:issn:1219-4956 |
|
dc.title |
Synergetic Insulin Sensitizing Effect of Rimonabant and BGP-15 in Zucker-Obes Rats |
|
dc.type |
Journal Article |
|
dc.date.updated |
2015-11-25T13:46:49Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
2286566 |
|
dc.identifier.wos |
000321973600029 |
|
dc.identifier.pubmed |
23640247 |
|
dc.contributor.department |
SE/AOK/I/Orvosi Vegytani, Molekuláris Biológiai és Patobiokémiai Intézet |
|
dc.contributor.institution |
Semmelweis Egyetem |
|