dc.contributor.author |
Downey CL |
|
dc.contributor.author |
Simpkins SA |
|
dc.contributor.author |
White J |
|
dc.contributor.author |
Holliday DL |
|
dc.contributor.author |
Jones JL |
|
dc.contributor.author |
Jordan LB |
|
dc.contributor.author |
Kulka, Janina |
|
dc.contributor.author |
Pollock S |
|
dc.contributor.author |
Rajan SS |
|
dc.contributor.author |
Thygesen HH |
|
dc.contributor.author |
Hanby AM |
|
dc.contributor.author |
Speirs V |
|
dc.date.accessioned |
2016-12-15T08:20:50Z |
|
dc.date.available |
2016-12-15T08:20:50Z |
|
dc.date.issued |
2014 |
|
dc.identifier |
84897570019 |
|
dc.identifier.citation |
pagination=1744-1747;
journalVolume=110;
journalIssueNumber=7;
journalTitle=BRITISH JOURNAL OF CANCER; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/2756 |
|
dc.description.abstract |
BACKGROUND:
A high percentage of stroma predicts poor survival in triple-negative breast cancers but is diminished in studies of unselected cases. We determined the prognostic significance of tumour-stroma ratio (TSR) in oestrogen receptor (ER)-positive male and female breast carcinomas.
METHODS:
TSR was measured in haematoxylin and eosin-stained tissue sections (118 female and 62 male). Relationship of TSR (cutoff 49%) to overall survival (OS) and relapse-free survival (RFS) was analysed.
RESULTS:
Tumours with ≥49% stroma were associated with better survival in female (OS P=0.008, HR=0.2-0.7; RFS P=0.006, HR=0.1-0.6) and male breast cancer (OS P=0.005, HR=0.05-0.6; RFS P=0.01, HR=0.87-5.6), confirmed in multivariate analysis.
CONCLUSIONS:
High stromal content was related to better survival in ER-positive breast cancers across both genders, contrasting data in triple-negative breast cancer and highlighting the importance of considering ER status when interpreting the prognostic value of TSR. |
|
dc.relation.ispartof |
urn:issn:0007-0920 |
|
dc.title |
The prognostic significance of tumour-stroma ratio in oestrogen receptor-positive breast cancer |
|
dc.type |
Journal Article |
|
dc.date.updated |
2015-11-25T14:01:26Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
2580656 |
|
dc.identifier.wos |
WOS:000334495700009 |
|
dc.contributor.department |
SE/AOK/I/II. Sz. Patológiai Intézet |
|
dc.contributor.institution |
Semmelweis Egyetem |
|