Kivonat:
The treatment of several central nervous system diseases is
impeded due to the unique structure of the brain and the
protecting
function of the blood-brain barrier. On the other hand,
the rapid elimination of drug particles and the consequent
low therapeutic response also poses challenges for the
pharmaceuticals.
Nowadays, the more detailed understanding of
the structure and pathophysiology of the blood-brain barrier
and the development of pharmaceutical sciences enable the
creation of drug delivery systems offering targeted brain
delivery.
The potential utilization of different types of nanoparticles
for targeted delivery purposes, such as liposomes, polymeric
nanoparticles and solid lipid nanocarriers have been
proven by numerous research papers. Furthermore, the
exploitation
of physiological pathways in drug delivery, such as
adsorption or cell mediated transcytosis has been gaining an
increasing interest, due to their better selectivity. The aim
of
this paper is to provide a comprehensive review on the modern
approaches for targeted brain drug delivery.