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dc.contributor.author Molvarec, Attila
dc.contributor.author Fügedi, Gergely
dc.contributor.author Szabó, Eszter
dc.contributor.author Stenczer, Balázs
dc.contributor.author Walentin S
dc.contributor.author Rigó, János
dc.date.accessioned 2017-01-20T09:19:53Z
dc.date.available 2017-01-20T09:19:53Z
dc.date.issued 2015
dc.identifier 84930520870
dc.identifier.citation pagination=413-418; journalVolume=38; journalIssueNumber=6; journalTitle=HYPERTENSION RESEARCH;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/2826
dc.identifier.uri doi:10.1038/hr.2015.20
dc.description.abstract The endocannabinoid system has a key role in female reproduction, including implantation, decidualization and placentation. A growing number of studies indicate that placental and peripheral blood anandamide levels correlate closely with both spontaneous miscarriage and ectopic pregnancy. Anandamide has also been implicated in blood pressure regulation. In this study, we aimed to determine circulating anandamide levels in preeclampsia for the first time in the literature. Forty-three preeclamptic patients and 71 healthy pregnant women were involved in this case-control study. Serum anandamide concentrations were determined by high-performance liquid chromatography-mass spectrometry technique. Serum total soluble fms-like tyrosine kinase-1 (sFlt-1) and biologically active placental growth factor (PlGF) levels were measured by electrochemiluminescence immunoassay. For statistical analyses, nonparametric methods were applied. Serum levels of anandamide were significantly lower in preeclamptic patients than in healthy pregnant women (0.75 (0.44-1.03) ng ml-1 vs. 1.30 (0.76-2.0) ng ml-1, P<0.001). Preeclamptic patients had significantly higher sFlt-1 levels (12 121 (7963-18 316) pg ml-1 vs. 2299 (1393-3179) pg ml-1, P<0.001) and significantly lower PlGF concentrations (71.2 (39.2-86.4) pg ml-1 vs. 256.8 (181.1-421.0) pg ml-1, P<0.001) as compared with healthy pregnant women. Serum anandamide concentrations did not correlate with serum levels of sFlt-1 and PlGF in our healthy pregnant and preeclamptic groups. In conclusion, we demonstrated for the first time in the literature that serum anandamide concentrations are decreased in women with preeclampsia. However, the cause and consequence of this observation remain to be determined.Hypertension Research advance online publication, 26 February 2015; doi:10.1038/hr.2015.20.
dc.relation.ispartof urn:issn:0916-9636
dc.title Decreased circulating anandamide levels in preeclampsia.
dc.type Journal Article
dc.date.updated 2015-11-27T08:31:41Z
dc.language.rfc3066 en
dc.identifier.mtmt 2851443
dc.identifier.wos 000355701800008
dc.identifier.pubmed 25716652
dc.contributor.department SE/AOK/K/I. Sz. Szülészeti és Nőgyógyászati Klinika
dc.contributor.department SE/AOK/K/I. Sz. Gyermekgyógyászati Klinika
dc.contributor.institution Semmelweis Egyetem


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