dc.contributor.author |
Folyovich, András |
|
dc.contributor.author |
Biro, Edina Márta |
|
dc.contributor.author |
Orbán, Csaba |
|
dc.contributor.author |
Bajnok A |
|
dc.contributor.author |
Varga V |
|
dc.contributor.author |
Béres-Molnár, Katalin Anna |
|
dc.contributor.author |
Vásárhelyi, Barna |
|
dc.contributor.author |
Toldi, Gergely |
|
dc.date.accessioned |
2015-04-16T12:46:23Z |
|
dc.date.available |
2015-04-16T12:46:23Z |
|
dc.date.issued |
2014 |
|
dc.identifier |
84896696979 |
|
dc.identifier.citation |
pagination=41, pages 7;
journalVolume=14;
journalIssueNumber=1;
journalTitle=BMC NEUROLOGY; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/283 |
|
dc.identifier.uri |
doi:10.1186/1471-2377-14-41 |
|
dc.description.abstract |
BACKGROUND: Acute ischemic stroke (AIS) has a biphasic effect on the peripheral immune system. The initial inflammatory response is followed by systemic immunosuppression, referred to as stroke-induced immunosuppression (SIIS), leading to severe complications in stroke patients. We aimed to identify an inflammatory marker that best represents this biphasic immunological response after AIS. METHODS: We investigated the alteration of CRP, WBC, neutrophil count, suPAR levels, CD4+ CD25high Tregs, CD64+ and CD177+ neutrophils and monocytes in 12 acute ischemic stroke patients free of infection within 6 hours and one week after the insult. As controls, 14 age-matched healthy individuals were included. RESULTS: CRP, WBC and neutrophil count values were comparable in stroke patients within 6 hours and controls, however, they were elevated in stroke one week after the insult. suPAR levels were higher in both stroke groups compared to controls. The prevalence of CD64+ neutrophils was higher in stroke patients within 6 hours than in controls and it decreased in stroke one week after the insult below the level in controls (5.95 [5.41-8.75] % vs. 32.38 [9.21-43.93] % vs. 4.06 [1.73-6.77] %, p < 0.05). CONCLUSIONS: Our pilot study identified that the prevalence of CD64+ neutrophils may reflect a biphasic alteration of the immune response following AIS. Since its level decreases below baseline after one week of the CNS insult in stroke patients without infection, it might serve as a reliable candidate to identify the developing inflammatory response due to infection after stroke in the future. |
|
dc.relation.ispartof |
urn:issn:1471-2377 |
|
dc.title |
Relevance of novel inflammatory markers in stroke-induced immunosuppression |
|
dc.type |
Journal Article |
|
dc.date.updated |
2014-07-29T07:28:36Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
2552547 |
|
dc.identifier.pubmed |
24597828 |
|
dc.contributor.department |
SE/ÁOK/I/Laboratóriumi Medicina Intézet-összevont 2010 -Központi Laboratórium és Kórélettani LabMed tszcsoport |
|
dc.contributor.institution |
Semmelweis Egyetem |
|
dc.mtmt.swordnote |
PMC PMC3948141 |
|