dc.contributor.author |
Mózes, Petra |
|
dc.contributor.author |
Hauser, Péter |
|
dc.contributor.author |
Hortobágyi, Tibor |
|
dc.contributor.author |
Benyo G |
|
dc.contributor.author |
Peták, István |
|
dc.contributor.author |
Garami, Miklós |
|
dc.contributor.author |
Cserháti, Adrienn |
|
dc.contributor.author |
Bartyik K |
|
dc.contributor.author |
Bognár, László |
|
dc.contributor.author |
Nagy, Zoltán |
|
dc.contributor.author |
Turányi, Eszter |
|
dc.contributor.author |
Hideghéty, Katalin |
|
dc.date.accessioned |
2017-01-20T10:11:28Z |
|
dc.date.available |
2017-01-20T10:11:28Z |
|
dc.date.issued |
2016 |
|
dc.identifier |
84941686499 |
|
dc.identifier.citation |
pagination=99-105;
journalVolume=126;
journalIssueNumber=1;
journalTitle=JOURNAL OF NEURO-ONCOLOGY; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/2859 |
|
dc.identifier.uri |
doi:10.1007/s11060-015-1938-3 |
|
dc.description.abstract |
The embryonal tumor with abundant neuropil and true rosettes is a rare and highly malignant variant of embryonal brain tumors. It usually affects infants and young children under the age of 4 years and exhibits a very aggressive course with a dismal prognosis. For the 68 cases reported to date the mean age at diagnosis was 25.42 months (range 3-57 months). Survival data are available for 48 children (including our case): the median overall survival is 13.0 months, though 6 (9 %) of the children have had a relative long survival (>30 months). The aggressive combined treatment, involving primary surgical tumor removal, adjuvant polychemotherapy, including high-dose chemotherapy with stem cell transplantation, radiotherapy and radiochemotherapy, might play an important role in the longer survival. We have performed a literature review and we present here a multimodal-treated case of a 2- year-old girl with a long survival, who was reoperated when recurrence occurred. The residual tumor demonstrated a good response to temozolomide radiochemotherapy (craniospinal axis + boost) and followed by maintenance temozolomide. The described complex aggressive treatment option might be considered for future cases of this tumor entity. |
|
dc.relation.ispartof |
urn:issn:0167-594X |
|
dc.title |
Evaluation of the good tumor response of embryonal tumor with abundant neuropil and true rosettes (ETANTR). |
|
dc.type |
Journal Article |
|
dc.date.updated |
2015-11-27T13:48:09Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
2946462 |
|
dc.identifier.pubmed |
26373296 |
|
dc.contributor.department |
SZTE/ÁOK/Onkoterápiás Klinika |
|
dc.contributor.department |
SE/AOK/K/II. Sz. Gyermekgyógyászati Klinika |
|
dc.contributor.department |
SE/AOK/I/I. Sz. Patológiai és Kísérleti Rákkutató Intézet |
|
dc.contributor.institution |
Szegedi Tudományegyetem |
|
dc.contributor.institution |
Semmelweis Egyetem |
|