Show simple item record Mózes, Petra Hauser, Péter Hortobágyi, Tibor Benyo G Peták, István Garami, Miklós Cserháti, Adrienn Bartyik K Bognár, László Nagy, Zoltán Turányi, Eszter Hideghéty, Katalin 2017-01-20T10:11:28Z 2017-01-20T10:11:28Z 2016
dc.identifier 84941686499
dc.identifier.citation pagination=99-105; journalVolume=126; journalIssueNumber=1; journalTitle=JOURNAL OF NEURO-ONCOLOGY;
dc.identifier.uri doi:10.1007/s11060-015-1938-3
dc.description.abstract The embryonal tumor with abundant neuropil and true rosettes is a rare and highly malignant variant of embryonal brain tumors. It usually affects infants and young children under the age of 4 years and exhibits a very aggressive course with a dismal prognosis. For the 68 cases reported to date the mean age at diagnosis was 25.42 months (range 3-57 months). Survival data are available for 48 children (including our case): the median overall survival is 13.0 months, though 6 (9 %) of the children have had a relative long survival (>30 months). The aggressive combined treatment, involving primary surgical tumor removal, adjuvant polychemotherapy, including high-dose chemotherapy with stem cell transplantation, radiotherapy and radiochemotherapy, might play an important role in the longer survival. We have performed a literature review and we present here a multimodal-treated case of a 2- year-old girl with a long survival, who was reoperated when recurrence occurred. The residual tumor demonstrated a good response to temozolomide radiochemotherapy (craniospinal axis + boost) and followed by maintenance temozolomide. The described complex aggressive treatment option might be considered for future cases of this tumor entity.
dc.relation.ispartof urn:issn:0167-594X
dc.title Evaluation of the good tumor response of embryonal tumor with abundant neuropil and true rosettes (ETANTR).
dc.type Journal Article 2015-11-27T13:48:09Z
dc.language.rfc3066 en
dc.identifier.mtmt 2946462
dc.identifier.pubmed 26373296
dc.contributor.department SZTE/ÁOK/Onkoterápiás Klinika
dc.contributor.department SE/AOK/K/II. Sz. Gyermekgyógyászati Klinika
dc.contributor.department SE/AOK/I/I. Sz. Patológiai és Kísérleti Rákkutató Intézet
dc.contributor.institution Szegedi Tudományegyetem
dc.contributor.institution Semmelweis Egyetem

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