dc.contributor.author |
Agoston EI |
|
dc.contributor.author |
Baranyai Z |
|
dc.contributor.author |
Dede, Kristóf |
|
dc.contributor.author |
Bodoky, György |
|
dc.contributor.author |
Kulka, Janina |
|
dc.contributor.author |
Bursics, Attila |
|
dc.contributor.author |
Harsányi, László |
|
dc.contributor.author |
Szász, Attila Marcell |
|
dc.date.accessioned |
2016-12-14T11:46:49Z |
|
dc.date.available |
2016-12-14T11:46:49Z |
|
dc.date.issued |
2015 |
|
dc.identifier.citation |
pagination=1460-1471;
journalVolume=156;
journalIssueNumber=36;
journalTitle=ORVOSI HETILAP; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/2864 |
|
dc.identifier.uri |
doi:10.1556/650.2015.30218 |
|
dc.description.abstract |
INTRODUCTION: Besides clinicopathological parameters, molecular markers can be very important, and further characterize colorectal carcinomas into chromosomally unstable, microsatellite instable and "CqG-island methylator phenotype" groups. AIM: To study the frequency of microsatellite instability using immunohistochemical evaluation of MLH1, MSH2, MSH6 and PMS2 proteins in colorectal carcinoma. METHOD: 122 colorectal carcinomas as well as in 69 paired liver metastases were evaluated. Additionally, prognostic and predictive potential of mismatch repair status was tested. RESULTS: Microsatellite instable phenotype was identified in 11.5% (14/122) of the tumours. There were no differences regarding staining intensity of tumour regions. Mismatch repair status was discordant in primaries vs. metastases in 20.2%. There was no difference in progression free- and overall survival according to mismatch repair status. The mismatch repair status was not predictive for survival within systemic therapy regimen groups. CONCLUSIONS: The subgroups of colorectal carcinomas could be evaluated in a larger and homogenised patient cohort to predict prognosis and response to therapy. Orv. Hetil., 2015, 156(36), 1460-1471. |
|
dc.relation.ispartof |
urn:issn:0030-6002 |
|
dc.title |
Mikroszatellita-instabilitás előfordulása, intratumoralis heterogenitása, prognosztikus és prediktív potenciálja primer colorectalis carcinomák és párosított májáttéteik sebészi kezelését követően |
|
dc.type |
Journal Article |
|
dc.date.updated |
2015-11-27T14:05:37Z |
|
dc.language.rfc3066 |
hu |
|
dc.identifier.mtmt |
2952380 |
|
dc.identifier.pubmed |
26320600 |
|
dc.contributor.department |
SE/AOK/K/I. Sz. Sebészeti Klinika |
|
dc.contributor.department |
SE/AOK/I/II. Sz. Patológiai Intézet |
|
dc.contributor.institution |
Semmelweis Egyetem |
|