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dc.contributor.author Papp, Veronika
dc.contributor.author Rókusz, András
dc.contributor.author Dezső, Katalin
dc.contributor.author Bugyik, Edina
dc.contributor.author Szabó, Vanessza
dc.contributor.author Paku, Sándor
dc.contributor.author Nagy, Péter
dc.date.accessioned 2016-09-09T07:55:45Z
dc.date.available 2016-09-09T07:55:45Z
dc.date.issued 2014
dc.identifier 84890850128
dc.identifier.citation pagination=56-65; journalVolume=23; journalIssueNumber=1; journalTitle=STEM CELLS AND DEVELOPMENT;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/2964
dc.identifier.uri doi:10.1089/scd.2013.0202
dc.description.abstract The hepatic stem cells reside periportally forming the canals of Hering in normal liver. They can be identified by their unique immunophenotype in rat. The oval cells, the progenies of stem cells invade deep the liver parenchyma after activation and differentiate into focally arranged small-and eventually trabecularly ordered regular hepatocytes. We have observed that upon the completion of intense oval cell reactions narrow ductular structures are present in the parenchyma, we propose to call them parenchymal ductules. These parenchymal ductules have the same immunophenotype [cytokeratin (CK)7-/CK19+/alpha-fetoprotein (AFP)-/delta-like protein (DLK)-] as the resting stem cells of the canals of Hering, but different from them reside scattered in the parenchyma. In our present experiments, we have investigated in an in vivo functional assay if the presence of these parenchymal ductules has any impact on a progenitor cell driven regeneration process. Parenchymal ductules were induced either by an established model of oval cell induction consisting of the administration of necrogenic dose of carbontetrachloride to 2-acetaminofluorene pretreated rats (AAF/CCl4) or a large necrogenic dose of diethylnitrosamine (DEN). The oval cells expanded faster and the foci evolved earlier after repeated injury in the livers with preexistent parenchymal ductules. When the animals were left to survive for one more year increased liver tumor formation was observed exclusively in the DEN treated rats. Thus, repeated oval cell reactions are not necessarily carcinogenic. We conclude that the expansion of hepatic stem cell compartment conceptually can be used to facilitate liver regeneration without an increased risk of tumorigenesis.
dc.relation.ispartof urn:issn:1547-3287
dc.title Expansion of Hepatic Stem Cell Compartment Boosts Liver Regeneration.
dc.type Journal Article
dc.date.updated 2015-12-07T14:21:47Z
dc.language.rfc3066 en
dc.identifier.mtmt 2463270
dc.identifier.wos 000328702500007
dc.identifier.pubmed 23952741
dc.contributor.department SE/AOK/I/I. Sz. Patológiai és Kísérleti Rákkutató Intézet
dc.contributor.institution Semmelweis Egyetem


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