Show simple item record Csákváry, Violetta Erhardt, Éva Vargha P Oroszlan G Bödecs, Tamás Török, Dóra Salamonné Toldy, Erzsébet Kovács L., Gábor 2016-09-08T13:49:13Z 2016-09-08T13:49:13Z 2012
dc.identifier 84868522291
dc.identifier.citation pagination=203-211; journalVolume=78; journalIssueNumber=4; journalTitle=HORMONE RESEARCH IN PAEDIATRICS;
dc.identifier.uri doi:10.1159/000342335
dc.description.abstract Background/Aims: The association of bone mass with body composition, bone turnover markers and gonadal steroids was examined in Hungarian children during pre- and midpuberty. Methods: Two hundred and thirty-seven 7- to 16-year-old subjects (56% girls) were investigated. Bone mineral density (BMD), fat mass and total and appendicular lean mass were estimated with dual-energy X-ray absorptiometry (Lunar Prodigy). The fat mass index and appendicular lean mass index (LMI) were calculated. Serum bone markers, parathyroid hormone, estradiol and testosterone were analyzed. Associations between variables were evaluated by multiple regression analysis. Results: During prepuberty, bone biomarkers, gonadal steroids and appendicular LMI were associated with bone mass in both genders (p < 0.05). During midpuberty, girls' bone turnover markers were negatively associated with bone mass (p < 0.001). In prepuberty, appendicular LMI and beta-crosslaps were predictors of bone mass in both genders. During midpuberty, appendicular LMI and gonadal steroids positively contributed to bone mass in both genders, while osteocalcin exerted a negative influence on total and L1- L4 spine BMD in girls and on L1-L4 BMD in boys (all p < 0.001). Conclusions: Predictors for bone development varied according to Tanner stage and gender. The most significant determinants of bone mass were appendicular LMI and estradiol.
dc.relation.ispartof urn:issn:1663-2818
dc.title Association of Lean and Fat Body Mass, Bone Biomarkers and Gonadal Steroids with Bone Mass during Pre- and Midpuberty
dc.type Journal Article 2015-12-09T07:29:35Z
dc.language.rfc3066 en
dc.identifier.mtmt 2141345
dc.identifier.wos 000311491100001
dc.identifier.pubmed 23147421
dc.contributor.department SE/AOK/K/II. Sz. Gyermekgyógyászati Klinika
dc.contributor.department PTE/Szentágothai János Kutatóközpont
dc.contributor.institution Semmelweis Egyetem
dc.contributor.institution Pécsi Tudományegyetem

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