dc.contributor.author |
Csákváry, Violetta |
|
dc.contributor.author |
Erhardt, Éva |
|
dc.contributor.author |
Vargha P |
|
dc.contributor.author |
Oroszlan G |
|
dc.contributor.author |
Bödecs, Tamás |
|
dc.contributor.author |
Török, Dóra |
|
dc.contributor.author |
Salamonné Toldy, Erzsébet |
|
dc.contributor.author |
Kovács L., Gábor |
|
dc.date.accessioned |
2016-09-08T13:49:13Z |
|
dc.date.available |
2016-09-08T13:49:13Z |
|
dc.date.issued |
2012 |
|
dc.identifier |
84868522291 |
|
dc.identifier.citation |
pagination=203-211;
journalVolume=78;
journalIssueNumber=4;
journalTitle=HORMONE RESEARCH IN PAEDIATRICS; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/2980 |
|
dc.identifier.uri |
doi:10.1159/000342335 |
|
dc.description.abstract |
Background/Aims: The association of bone mass with body
composition, bone turnover markers and gonadal steroids was
examined in Hungarian children during pre- and midpuberty.
Methods: Two hundred and thirty-seven 7- to 16-year-old subjects
(56% girls) were investigated. Bone mineral density (BMD), fat
mass and total and appendicular lean mass were estimated with
dual-energy X-ray absorptiometry (Lunar Prodigy). The fat mass
index and appendicular lean mass index (LMI) were calculated.
Serum bone markers, parathyroid hormone, estradiol and
testosterone were analyzed. Associations between variables were
evaluated by multiple regression analysis. Results: During
prepuberty, bone biomarkers, gonadal steroids and appendicular
LMI were associated with bone mass in both genders (p < 0.05).
During midpuberty, girls' bone turnover markers were negatively
associated with bone mass (p < 0.001). In prepuberty,
appendicular LMI and beta-crosslaps were predictors of bone mass
in both genders. During midpuberty, appendicular LMI and gonadal
steroids positively contributed to bone mass in both genders,
while osteocalcin exerted a negative influence on total and L1-
L4 spine BMD in girls and on L1-L4 BMD in boys (all p < 0.001).
Conclusions: Predictors for bone development varied according to
Tanner stage and gender. The most significant determinants of
bone mass were appendicular LMI and estradiol. |
|
dc.relation.ispartof |
urn:issn:1663-2818 |
|
dc.title |
Association of Lean and Fat Body Mass, Bone Biomarkers and Gonadal Steroids with Bone Mass during Pre- and Midpuberty |
|
dc.type |
Journal Article |
|
dc.date.updated |
2015-12-09T07:29:35Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
2141345 |
|
dc.identifier.wos |
000311491100001 |
|
dc.identifier.pubmed |
23147421 |
|
dc.contributor.department |
SE/AOK/K/II. Sz. Gyermekgyógyászati Klinika |
|
dc.contributor.department |
PTE/Szentágothai János Kutatóközpont |
|
dc.contributor.institution |
Semmelweis Egyetem |
|
dc.contributor.institution |
Pécsi Tudományegyetem |
|