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dc.contributor.author Müller, Katalin Eszter
dc.contributor.author Lakatos, Péter László
dc.contributor.author Kovacs JB
dc.contributor.author Arató, András
dc.contributor.author Herczegné Várkonyi, Ágnes
dc.contributor.author Nemes, Éva
dc.contributor.author Tárnok, András
dc.contributor.author Tóth, Gergely Péter
dc.contributor.author Papp, Mária
dc.contributor.author Solyom E
dc.contributor.author Horvath A
dc.contributor.author Guthy I
dc.contributor.author Kovacs M
dc.contributor.author Hungarian IBD Registry Group (HUPIR)
dc.contributor.author Veres, Gábor
dc.date.accessioned 2016-05-27T08:51:37Z
dc.date.available 2016-05-27T08:51:37Z
dc.date.issued 2016
dc.identifier.citation pagination=50-55; journalVolume=62; journalIssueNumber=1; journalTitle=JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/3006
dc.identifier.uri doi:10.1097/MPG.0000000000000885
dc.description.abstract OBJECTIVES: Predicting short-term relapses and long-term prognosis is of utmost importance in paediatric inflammatory bowel disease (IBD). Our aim was to investigate the short-term disease outcome and medication during the first year in a paediatric incident cohort from Hungary. In addition, association laboratory markers and disease activity indices with short-term disease outcome and medication were analysed. METHODS: From January 1, 2008 to December 31, 2010, demographic data and clinical characteristics of newly diagnosed paediatric patients with IBD < 18 years of age were prospectively recorded. RESULTS: A total of 420 patients were identified (Crohn disease [CD] 266 and ulcerative colitis [UC] 124). Initially, 48% (124/256) of the patients with CD had moderate-to-severe disease (Pediatric Crohn's Disease Activity Index [PCDAI] > 31), and this rate decreased to 2.1% at 1-year follow-up. Proportion of patients with UC with moderate-to-severe disease (Pediatric Ulcerative Colitis Activity Index > 35) at diagnosis declined from 57.5% (69/120) to 6.8% at 1-year follow-up. Terminal ileal involvement correlated with higher initial C-reactive protein (CRP) (P = 0.021) and initial PCDAI (P = 0.026). In UC, elevated CRP (P = 0.002) was associated with disease extension. CRP and PCDAI at diagnosis were associated with the need for immunomodulators at 1 year in children with CD. Initial CRP was also associated with the need for immunomodulators in patients with UC at 1-year follow-up. CONCLUSIONS: At diagnosis, half of the patients with IBD had moderate-to-severe disease, and this rate decreased to <10% after 1 year. Initial CRP and PCDAI were related to the need for aggressive therapy in CD.
dc.relation.ispartof urn:issn:0277-2116
dc.title Baseline characteristics and disease phenotype in inflammatory bowel disease results of a paediatric IBD cohort
dc.type Journal Article
dc.date.updated 2016-01-07T08:27:10Z
dc.language.rfc3066 en
dc.identifier.mtmt 2900857
dc.identifier.pubmed 26192700
dc.contributor.department SE/AOK/K/I. Sz. Gyermekgyógyászati Klinika
dc.contributor.institution Semmelweis Egyetem


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