Show simple item record Müller, Katalin Eszter Lakatos, Péter László Kovacs JB Arató, András Herczegné Várkonyi, Ágnes Nemes, Éva Tárnok, András Tóth, Gergely Péter Papp, Mária Solyom E Horvath A Guthy I Kovacs M Hungarian IBD Registry Group (HUPIR) Veres, Gábor 2016-05-27T08:51:37Z 2016-05-27T08:51:37Z 2016
dc.identifier.citation pagination=50-55; journalVolume=62; journalIssueNumber=1; journalTitle=JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION;
dc.identifier.uri doi:10.1097/MPG.0000000000000885
dc.description.abstract OBJECTIVES: Predicting short-term relapses and long-term prognosis is of utmost importance in paediatric inflammatory bowel disease (IBD). Our aim was to investigate the short-term disease outcome and medication during the first year in a paediatric incident cohort from Hungary. In addition, association laboratory markers and disease activity indices with short-term disease outcome and medication were analysed. METHODS: From January 1, 2008 to December 31, 2010, demographic data and clinical characteristics of newly diagnosed paediatric patients with IBD < 18 years of age were prospectively recorded. RESULTS: A total of 420 patients were identified (Crohn disease [CD] 266 and ulcerative colitis [UC] 124). Initially, 48% (124/256) of the patients with CD had moderate-to-severe disease (Pediatric Crohn's Disease Activity Index [PCDAI] > 31), and this rate decreased to 2.1% at 1-year follow-up. Proportion of patients with UC with moderate-to-severe disease (Pediatric Ulcerative Colitis Activity Index > 35) at diagnosis declined from 57.5% (69/120) to 6.8% at 1-year follow-up. Terminal ileal involvement correlated with higher initial C-reactive protein (CRP) (P = 0.021) and initial PCDAI (P = 0.026). In UC, elevated CRP (P = 0.002) was associated with disease extension. CRP and PCDAI at diagnosis were associated with the need for immunomodulators at 1 year in children with CD. Initial CRP was also associated with the need for immunomodulators in patients with UC at 1-year follow-up. CONCLUSIONS: At diagnosis, half of the patients with IBD had moderate-to-severe disease, and this rate decreased to <10% after 1 year. Initial CRP and PCDAI were related to the need for aggressive therapy in CD.
dc.relation.ispartof urn:issn:0277-2116
dc.title Baseline characteristics and disease phenotype in inflammatory bowel disease results of a paediatric IBD cohort
dc.type Journal Article 2016-01-07T08:27:10Z
dc.language.rfc3066 en
dc.identifier.mtmt 2900857
dc.identifier.pubmed 26192700
dc.contributor.department SE/AOK/K/I. Sz. Gyermekgyógyászati Klinika
dc.contributor.institution Semmelweis Egyetem

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