The emerging and diverse roles of Src-like adaptor proteins in health and disease

dc.contributor.author	Marton, Nikolett
dc.contributor.author	Baricza, Eszter
dc.contributor.author	Molnár-Érsek, Barbara
dc.contributor.author	Buzás, Edit Irén
dc.contributor.author	Nagy, György
dc.date.accessioned	2017-06-27T09:26:04Z
dc.date.available	2017-06-27T09:26:04Z
dc.date.issued	2015
dc.identifier	84939615547
dc.identifier.citation	pagination=952536, 9 pages; journalVolume=2015; journalTitle=MEDIATORS OF INFLAMMATION;
dc.identifier.uri	http://repo.lib.semmelweis.hu//handle/123456789/3014
dc.identifier.uri	doi:10.1155/2015/952536
dc.description.abstract	Although Src-like adaptor proteins (SLAP-1 and SLAP-2) were mainly studied in lymphocytes, where they act as negative regulators and provide fine control of receptor signaling, recently, several other functions of these proteins were discovered. In addition to the well-characterized immunoregulatory functions, SLAP proteins appear to have an essential role in the pathogenesis of type I hypersensitivity, osteoporosis, and numerous malignant diseases. Both adaptor proteins are expressed in a wide variety of tissues, where they have mostly inhibitory effects on multiple intracellular signaling pathways. In this review, we summarize the diverse effects of SLAP proteins.
dc.relation.ispartof	urn:issn:0962-9351
dc.title	The emerging and diverse roles of Src-like adaptor proteins in health and disease
dc.type	Journal Article
dc.date.updated	2016-01-12T13:35:07Z
dc.language.rfc3066	en
dc.identifier.mtmt	2820907
dc.identifier.wos	000359582400001
dc.identifier.pubmed	26339145
dc.contributor.department	SE/AOK/I/Genetikai, Sejt- és Immunbiológiai Intézet
dc.contributor.institution	Semmelweis Egyetem
dc.mtmt.swordnote	FELTÖLTŐ: Ádám Adrienn - adamadrienn78@gmail.com