dc.contributor.author |
Kalász, Huba |
|
dc.contributor.author |
Magyar, Kálmán |
|
dc.contributor.author |
Szőke, Éva |
|
dc.contributor.author |
Adeghate, Ernest Akingunola |
|
dc.contributor.author |
Adem, A |
|
dc.contributor.author |
Tekes, Kornélia |
|
dc.date.accessioned |
2016-03-30T09:41:57Z |
|
dc.date.available |
2016-03-30T09:41:57Z |
|
dc.date.issued |
2014 |
|
dc.identifier |
84899798478 |
|
dc.identifier.citation |
pagination=1522-1530;
journalVolume=21;
journalIssueNumber=13;
journalTitle=CURRENT MEDICINAL CHEMISTRY; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/3027 |
|
dc.identifier.uri |
doi:10.2174/0929867321666131218094352 |
|
dc.description.abstract |
Selegiline [(-)-deprenyl] is used to treat patients with Parkinson's disease. Nevertheless, in much higher doses it has beneficial effects in depression, and dementia of the aged patients. Selegiline undergoes a complex metabolic pathway. Its major metabolites include desmethylselegiline, (-)-methamphetamine and (-)-amphetamine, selegiline-N-oxide and formaldehyde as a small metabolic fragment in animal experiments. In addition, more than 40 minor metabolites of selegiline have also been either detected or proposed by investigators and researchers. This review analyses the pharmacological activity, generation pathway and the detection method of the major metabolites of selegiline. |
|
dc.relation.ispartof |
urn:issn:0929-8673 |
|
dc.title |
Metabolism of Selegiline [(-)-Deprenyl)] |
|
dc.type |
Journal Article |
|
dc.date.updated |
2016-01-25T09:22:59Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
2483176 |
|
dc.identifier.wos |
000333425700004 |
|
dc.identifier.pubmed |
24350849 |
|
dc.contributor.department |
SE/GYTK/Farmakognózia Intézet |
|
dc.contributor.department |
SE/GYTK/Gyógyszerhatástani Intézet |
|
dc.contributor.institution |
Semmelweis Egyetem |
|