dc.contributor.author |
Benczik M |
|
dc.contributor.author |
Galamb, Ádám |
|
dc.contributor.author |
Koiss R |
|
dc.contributor.author |
Kovacs A |
|
dc.contributor.author |
Járay, Balázs |
|
dc.contributor.author |
Székely, Tamás |
|
dc.contributor.author |
Schaff, Zsuzsa |
|
dc.contributor.author |
Sobel, Gábor |
|
dc.contributor.author |
Jeney, Csaba |
|
dc.date.accessioned |
2016-09-07T06:43:20Z |
|
dc.date.available |
2016-09-07T06:43:20Z |
|
dc.date.issued |
2016 |
|
dc.identifier |
84951574284 |
|
dc.identifier.citation |
pagination=179-188;
journalVolume=22;
journalIssueNumber=1;
journalTitle=PATHOLOGY AND ONCOLOGY RESEARCH; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/3046 |
|
dc.identifier.uri |
doi:10.1007/s12253-015-9990-z |
|
dc.description.abstract |
Several immunochemistry tests are used for triaging human papilloma virus (HPV) and cytology positive cases in cervical cancer screening and as an adjunct test to diagnose cervical cancer. Claudin-1 (CLDN1) protein is a major component of the tight junction, shown to have altered expression in cervical cancer. In this study, value of CLDN1 was analysed as a screening and triage immunochemistry test compared to cytology and HPV testing. A population of 352 women attending colposcopic referral visits resulting in cervical conisation and a second population of 150 women attending routine gynaecological visits with negative cervical cytology were enrolled in a multi-centre clinical study in Hungary. Cytology and HPV (Genoid Full Spectrum HPV Amplification and Detection System) testing were carried out along with immunocytochemistry for CLDN1, and as a reference, using CINtec p16 Cytology Kit. Three different evaluation protocols were used which assessed immunostaining characteristics with or without cytological readings. High correlation observable between p16INK4a and CLDN1 established CLDN1 as a competing marker in cervical cancer. Concordance of CLDN1 immunostaining of cervical intraepithelial neoplasia 2 and above (CIN2+) positives was 84.0 % (73.8-89.3); concordance of CIN2+ negatives was 69.0 % (59.6-75.8). In conclusion, CLDN1 has similar diagnostic potential as p16INK4a, our results established it as a histological and cytological biomarker with the potential to improve the clinical performance of cervical cytology and histology. |
|
dc.relation.ispartof |
urn:issn:1219-4956 |
|
dc.title |
Claudin-1 as a Biomarker of Cervical Cytology and Histology. |
|
dc.type |
Journal Article |
|
dc.date.updated |
2016-01-28T10:34:34Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
2963615 |
|
dc.identifier.wos |
000366646400025 |
|
dc.identifier.pubmed |
26463354 |
|
dc.contributor.department |
SE/AOK/K/II. Sz. Szülészeti és Nőgyógyászati Klinika |
|
dc.contributor.department |
SE/AOK/I/II. Sz. Patológiai Intézet |
|
dc.contributor.department |
SE/AOK/I/Orvosi Mikrobiológiai Intézet |
|
dc.contributor.institution |
Semmelweis Egyetem |
|