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dc.contributor.author Bubenyák, Máté Dániel
dc.contributor.author Noszál, Béla
dc.contributor.author Koczian K,
dc.contributor.author Takacs M,
dc.contributor.author Béni, Szabolcs
dc.contributor.author Hermecz, István
dc.contributor.author Kökösi, József
dc.date.accessioned 2016-02-18T12:35:32Z
dc.date.available 2016-02-18T12:35:32Z
dc.date.issued 2008
dc.identifier 49549090662
dc.identifier.citation pagination=5711-5713; journalVolume=49; journalIssueNumber=40; journalTitle=TETRAHEDRON LETTERS;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/3092
dc.identifier.uri doi:10.1016/j.tetlet.2008.07.098
dc.description.abstract Bioisosteric replacements were accomplished by building the structural elements of piroxicam, an antiinflammatory drug, into the pentacyclic system of rutaecarpine, a quinazolinocarboline alkaloid, in order to modify activity and selectivity on COX-isoenzymes. The pentacyclic compounds were synthesized efficiently by employing 1-oxo-9,10,11,12-tetrahydro-4H-pyrido[1,2-b] 1,2-benzothiazine 5,5-dioxide as a key intermediate, and prepared by alternative routes. Condensation of the tricyclic ketone with arylhydrazines and subsequent Fischer-indolization provided the first representatives of new heterocyclic ring systems 3 and 4. Crown Copyright (C) 2008 Published by Elsevier Ltd. All Fights reserved.
dc.relation.ispartof urn:issn:0040-4039
dc.title Bioisosteric hybrids of two anti-inflammatory agents, rutaecarpine and piroxicam
dc.type Journal Article
dc.date.updated 2016-02-15T10:12:03Z
dc.language.rfc3066 en
dc.identifier.mtmt 1475845
dc.identifier.wos 000259537800001
dc.contributor.department SE/GYTK/Egyetemi Gyógyszertár Gyógyszerügyi Szervezési Intézet
dc.contributor.department SE/GYTK/Gyógyszerészi Kémiai Intézet
dc.contributor.institution Semmelweis Egyetem


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