dc.contributor.author |
Petroianu G, |
|
dc.contributor.author |
Szőke, Éva |
|
dc.contributor.author |
Kalász, Huba |
|
dc.contributor.author |
Szegi, Péter |
|
dc.contributor.author |
Laufer, Rudolf |
|
dc.contributor.author |
Darvas, Ferenc |
|
dc.contributor.author |
Tekes, Kornélia |
|
dc.date.accessioned |
2016-03-30T07:40:49Z |
|
dc.date.available |
2016-03-30T07:40:49Z |
|
dc.date.issued |
2009 |
|
dc.identifier |
77953441328 |
|
dc.identifier.citation |
pagination=1-7;
journalVolume=3;
journalTitle=THE OPEN MEDICINAL CHEMISTRY JOURNAL; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/3162 |
|
dc.identifier.uri |
doi:10.2174/1874104500903010001 |
|
dc.description.abstract |
Three major flavonoid chamomile components (quercetin, apigenin-7-O- glucoside and rutin) were subjected to oxidative metabolism by cytochrome P-450 of rat liver microsomal preparations. Changes over time in their respective concentrations were followed using reversed-phase HPLC with UV detection. No clean-up had to be applied as only the specific flavonoid had to be separated from the background components originating from the rat liver microsome. Neither the concentration of apigenin-7-O-glucoside nor that of the diglycoside rutin decreased during one hour of exposure to rat microsomal treatment. In contrast, the concentration of quercetin, a lipophilic aglycon, decreased. Our analytical HPLC results complement the in silico calculated lipophilicity (logP) of these compounds; the relatively high lipophilicity of quercetin appears to predispose it to oxidative metabolism in order to decrease its fat solubility. In contrast the much less lipophilic compounds apigenin-7-O-glucoside and rutin were resistant in vitro to microsomal treatment. © A.A. El Maghraby; Licensee Bentham Open. |
|
dc.relation.ispartof |
urn:issn:1874-1045 |
|
dc.title |
Monitoring by HPLC of chamomile flavonoids exposed to rat liver microsomal metabolism |
|
dc.type |
Journal Article |
|
dc.date.updated |
2016-03-07T13:36:37Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
1449476 |
|
dc.contributor.department |
Semmelweis Egyetem |
|
dc.contributor.department |
SE/GYTK/Farmakognózia Intézet |
|
dc.contributor.institution |
Semmelweis Egyetem |
|