dc.contributor.author |
Magnani L |
|
dc.contributor.author |
Stoeck A |
|
dc.contributor.author |
Zhang X |
|
dc.contributor.author |
Lánczky A |
|
dc.contributor.author |
Mirabella AC |
|
dc.contributor.author |
Győrffy Balázs |
|
dc.date.accessioned |
2014-10-20T12:07:26Z |
|
dc.date.available |
2014-10-20T12:07:26Z |
|
dc.date.issued |
2013 |
|
dc.identifier.citation |
pagination=E1490-E1499;journalVolume=110;journalIssueNumber=16;journalTitle=PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; |
hu |
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/325 |
|
dc.identifier.uri |
doi:10.1073/pnas.1219992110 |
|
dc.description.abstract |
The estrogen receptor (ER)α drives growth in two-thirds of all breast cancers. Several targeted therapies, collectively termed endocrine therapy, impingeonestrogen-induced ERα activationtoblock tumor growth. However, half ofERα-positive breast cancers are tolerant or acquire resistance to endocrine therapy. We demonstrate that genome-wide reprogramming of the chromatin landscape, defined by epigenomic maps for regulatory elements or transcriptional activation and chromatin openness, underlies resistance to endocrine therapy. This annotation reveals endocrine therapy-response specific regulatory networks where NOTCH pathway is overactivated in resistant breast cancer cells, whereas classical ERα signaling is epige-netically disengaged. Blocking NOTCH signaling abrogates growth of resistant breast cancer cells. Its activation state in primary breast tumors is a prognostic factor of resistance in endocrine treated patients. Overall, our work demonstrates that chromatin landscape reprogramming underlies changes in regulatory networks driving endocrine therapy resistance in breast cancer. |
|
dc.relation.ispartof |
urn:issn:0027-8424 |
|
dc.title |
Genome-wide reprogramming of the chromatin landscape underlies endocrine therapy resistance in breast cancer |
hu |
dc.type |
Journal Article |
hu |
dc.date.updated |
2014-08-12T10:24:39Z |
|
dc.language.rfc3066 |
en |
hu |
dc.identifier.mtmt |
2278387 |
|
dc.identifier.wos |
000318041500009 |
|
dc.identifier.pubmed |
23576735 |
|
dc.contributor.department |
SE/ÁOK/K/ISZGYK/MTA-SE Gyermekgyógyászati és Nephrológiai Kutatócsoport |
|
dc.contributor.institution |
Semmelweis Egyetem |
|