Show simple item record Patai, Árpád V Molnár, Béla Kalmár, Alexandra Schöller, Andrea Tóth, Kinga Tulassay, Zsolt 2016-07-20T10:31:15Z 2016-07-20T10:31:15Z 2012
dc.identifier 84862861689
dc.identifier.citation pagination=310-315; journalVolume=30; journalIssueNumber=3; journalTitle=DIGESTIVE DISEASES;
dc.identifier.uri doi:10.1159/000337004
dc.description.abstract Colorectal cancer is the most common malignancy of the gastrointestinal tract and a leading cause of cancer-related deaths worldwide. In order to detect early precursor lesions, colonoscopy is widely used. Unfortunately, patient adherence to colonoscopy is poor, which is partially due to the modest performance of currently used prescreening tests. Recently, epigenetics added an additional layer to the understanding of colorectal carcinogenesis. DNA methylation as part of the epigenetic gene-silencing complex is a universally occurring change in colorectal cancer and arises prior to the onset of recognizable preneoplastic changes, which may have huge preventive implications. Herein we discuss the major developments in the field of colorectal carcinogenesis and DNA methylation, including alterations in nonneoplastic conditions such as aging and ulcerative colitis. We try to demonstrate how this epigenetic modification can be harnessed to address some of the key issues impeding the successful clinical management of colorectal cancer. Copyright (C) 2012 S. Karger AG, Basel
dc.relation.ispartof urn:issn:0257-2753
dc.title Role of DNA Methylation in Colorectal Carcinogenesis
dc.type Journal Article 2016-05-31T08:17:16Z
dc.language.rfc3066 en
dc.identifier.mtmt 2091218
dc.identifier.wos 000305680600011
dc.identifier.pubmed 22722557
dc.contributor.department SE/AOK/K/II. Sz. Belgyógyászati Klinika
dc.contributor.department SE/AOK/K/IISZBK/MTA-SE Molekuláris Medicina Kutatócsoport (2006-ig: MTA-SE Gastroenterológiai és Endocrinológiai Kutatócsoport)
dc.contributor.institution Semmelweis Egyetem

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