dc.contributor.author |
Kakuszi B |
|
dc.contributor.author |
Tombor, László |
|
dc.contributor.author |
Papp, Szilvia |
|
dc.contributor.author |
Bitter, István |
|
dc.contributor.author |
Czobor, Pál |
|
dc.date.accessioned |
2016-07-20T10:41:28Z |
|
dc.date.available |
2016-07-20T10:41:28Z |
|
dc.date.issued |
2016 |
|
dc.identifier.citation |
pagination=57-66;
journalVolume=249;
journalTitle=PSYCHIATRY RESEARCH-NEUROIMAGING; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/3421 |
|
dc.identifier.uri |
doi:10.1016/j.pscychresns.2016.02.008 |
|
dc.description.abstract |
Aberrations in early-developing bottom-up processes, such as stimulus-driven response preparation, are thought to play a critical role in the onset of ADHD, and in its persistence over time. Electrophysiology offers a unique tool to gain insight into response preparation, since response preparation has been associated with distinctive ERP changes, including negative potential-shifts which occur predominantly over frontal brain areas. We examined response-preceding negative potential shifts (RPNS) as a probe of response-preparation in adult ADHD patients by obtaining high-density event-related potentials from 33 ADHD and 29 matched healthy subjects during a Go/Nogo task using a 128-channel BioSemi recording-system. Compared to controls, ADHD patients showed enhancement of the RPNS in fronto-central brain regions in the Go condition during correct responses. This change was associated with poor performance in the Stroop incongruency-task: the greater the enhancement, the higher the proportion of errors. Moreover, the ERP-enhancement showed association with the severity of ADHD-symptoms; and with heightened response-variability. Thus, ADHD patients demonstrate neurophysiological alterations in response-preparation and response-preceding brain activity, suggestive of excessive activation of prefrontal neural circuits. Given the correlation with neuropsychological and psychopathological measures, these changes may constitute a pathway for core symptoms of ADHD, including premature and impaired response-preparation and motor-hyperactivity. |
|
dc.relation.ispartof |
urn:issn:0925-4927 |
|
dc.title |
Altered response-preparation in patients with adult ADHD: A high-density ERP study. |
|
dc.type |
Journal Article |
|
dc.date.updated |
2016-05-31T09:59:42Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
3071304 |
|
dc.identifier.pubmed |
27000308 |
|
dc.contributor.department |
SE/AOK/K/Pszichiátriai és Pszichoterápiás Klinika |
|
dc.contributor.institution |
Semmelweis Egyetem |
|