dc.contributor.author |
Ghanim B |
|
dc.contributor.author |
Klikovits T |
|
dc.contributor.author |
Hoda MA |
|
dc.contributor.author |
Lang, György |
|
dc.contributor.author |
Szirtes, Ildikó |
|
dc.contributor.author |
Setinek U |
|
dc.contributor.author |
Rozsas A |
|
dc.contributor.author |
Rényi-Vámos, Ferenc István |
|
dc.contributor.author |
Laszlo V |
|
dc.contributor.author |
Grusch M |
|
dc.contributor.author |
Filipits M |
|
dc.contributor.author |
Scheed A |
|
dc.contributor.author |
Jakopovic M |
|
dc.contributor.author |
Samarzija M |
|
dc.contributor.author |
Brcic L |
|
dc.contributor.author |
Stancic-Rokotov D |
|
dc.contributor.author |
Kern I |
|
dc.contributor.author |
Rozman A |
|
dc.contributor.author |
Dekan G |
|
dc.contributor.author |
Klepetko W |
|
dc.contributor.author |
Berger W |
|
dc.contributor.author |
Glasz, Tibor |
|
dc.contributor.author |
Döme, Balázs |
|
dc.contributor.author |
Hegedűs, Balázs |
|
dc.date.accessioned |
2016-10-24T10:40:49Z |
|
dc.date.available |
2016-10-24T10:40:49Z |
|
dc.date.issued |
2015 |
|
dc.identifier |
84928701217 |
|
dc.identifier.citation |
pagination=783-792;
journalVolume=112;
journalIssueNumber=5;
journalTitle=BRITISH JOURNAL OF CANCER; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/3484 |
|
dc.identifier.uri |
doi:10.1038/bjc.2015.9 |
|
dc.description.abstract |
BACKGROUND: Estimating the prognosis in malignant pleural mesothelioma (MPM) remains challenging. Thus, the prognostic relevance of Ki67 was studied in MPM. METHODS: Ki67 index was determined in a test cohort of 187 cases from three centres. The percentage of Ki67-positive tumour cells was correlated with clinical variables and overall survival (OS). The prognostic power of Ki67 index was compared with other prognostic factors and re-evaluated in an independent cohort (n=98). RESULTS: Patients with Ki67 higher than median (>15%) had significantly (P<0.001) shorter median OS (7.5 months) than those with low Ki67 (19.1 months). After multivariate survival analyses, Ki67 proved to be-beside histology and treatment-an independent prognostic marker in MPM (hazard ratio (HR): 2.1, P<0.001). Interestingly, Ki67 was prognostic exclusively in epithelioid (P<0.001) but not in non-epithelioid subtype. Furthermore, Ki67 index was significantly lower in post-chemotherapy samples when compared with chemo-naive cases. The prognostic power was comparable to other recently published prognostic factors (CRP, fibrinogen, neutrophil-to-leukocyte ratio (NLR) and nuclear grading score) and was recapitulated in the validation cohort (P=0.048). CONCLUSION: This multicentre study demonstrates that Ki67 is an independent and reproducible prognostic factor in epithelioid but not in non-epithelioid MPM and suggests that induction chemotherapy decreases the proliferative capacity of MPM. |
|
dc.relation.ispartof |
urn:issn:0007-0920 |
|
dc.title |
Ki67 index is an independent prognostic factor in epithelioid but not in non-epithelioid malignant pleural mesothelioma: a multicenter study |
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dc.type |
Journal Article |
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dc.date.updated |
2016-06-09T09:40:44Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
2907521 |
|
dc.identifier.wos |
000351384800002 |
|
dc.identifier.pubmed |
25633038 |
|
dc.contributor.department |
SE/AOK/K/Mellkassebészeti Klinika |
|
dc.contributor.department |
SE/AOK/I/II. Sz. Patológiai Intézet |
|
dc.contributor.institution |
Semmelweis Egyetem |
|
dc.mtmt.swordnote |
B Ghanim and T Klikovits authors contributed equally to the study.
B Dome and B Hegedus authors are co-senior authors of this study. |
|