dc.contributor.author |
Kertesz S |
|
dc.contributor.author |
Szabo G |
|
dc.contributor.author |
Udvari, Szabolcs |
|
dc.contributor.author |
Lévay, György István |
|
dc.contributor.author |
Mátyus, Péter |
|
dc.contributor.author |
Hársing, László Gábor |
|
dc.date.accessioned |
2014-11-16T15:30:58Z |
|
dc.date.available |
2014-11-16T15:30:58Z |
|
dc.date.issued |
2013 |
|
dc.identifier |
84871928555 |
|
dc.identifier.citation |
pagination=1-6;
journalVolume=1492;
journalTitle=BRAIN RESEARCH; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/358 |
|
dc.identifier.uri |
doi:10.1016/j.brainres.2012.11.025 |
|
dc.description.abstract |
We used isolated chicken retina to induce spreading depression by the glutamate receptor agonist N-methyl-d-aspartate. The N-methyl-d-aspartate- induced latency time of spreading depression was extended by the glycine B binding site competitive antagonist 7-chlorokynurenic acid. Addition of the glycine transporter type-1 inhibitors NFPS and Org-24461 reversed the inhibitory effect of 7-chlorokynurenic acid on N-methyl-d- aspartate-evoked spreading depression. The glycine uptake inhibitory activity of Org-24461, NFPS, and some newly synthesized analogs of NFPS was determined in CHO cells stably expressing human glycine transporter type-1b isoform. Compounds, which failed to inhibit glycine transporter type-1, also did not have effect on retinal spreading depression. These experiments indicate that the spreading depression model in chicken retina is a useful in vitro test to determine activity of glycine transporter type-1 inhibitors. In addition, our data serve further evidence for the role of glycine transporter type-1 in retinal neurotransmission and light processing. © 2012 Elsevier B.V. |
|
dc.relation.ispartof |
urn:issn:0006-8993 |
|
dc.title |
Temporal alteration of spreading depression by the glycine transporter type-1 inhibitors NFPS and Org-24461 in chicken retina |
|
dc.type |
Journal Article |
|
dc.date.updated |
2014-08-18T18:51:13Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
2165087 |
|
dc.identifier.wos |
000314321800001 |
|
dc.identifier.pubmed |
23178696 |
|
dc.contributor.department |
SE/GYTK/Szerves Vegytani Intézet |
|
dc.contributor.department |
SE/ETK2007/AEI/Morfológiai és Fiziológiai Tanszék |
|
dc.contributor.department |
SE/AOK/I/Farmakológiai és Farmakoterápiás Intézet |
|
dc.contributor.institution |
Semmelweis Egyetem |
|