Show simple item record Toldi, Gergely Stenczer, Balázs Treszl, András Kollár, Szonja Molvarec, Attila Tulassay, Tivadar Rigó, János Vásárhelyi, Barna 2016-08-22T07:19:56Z 2016-08-22T07:19:56Z 2011
dc.identifier 78650973708
dc.identifier.citation pagination=154-163; journalVolume=65; journalIssueNumber=2; journalTitle=AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY;
dc.identifier.uri doi:10.1111/j.1600-0897.2010.00899.x
dc.description.abstract Problem Calcium handling of T lymphocytes is altered in healthy pregnancy (HP) and preeclampsia (PE) compared to non-pregnant (non-P) women. We compared the activation-elicited calcium influx in T lymphocytes in HP, PE and non-P women and tested its alteration upon inhibition of Kv1.3 and IKCa1 potassium channels. Method of study The alteration of calcium influx was measured in major T-lymphocyte subsets of 9 non-P, HP and PE women with flow cytometry with or without treatment of cells with potassium channel inhibitors. Results The elicited calcium response was lower in HP compared to non-P. In HP, calcium influx was sensitive to potassium channel inhibition in CD8 and Th1, but not in Th2 cells. In PE, calcium influx and its sensitivity to inhibition were comparable to non-P. Conclusion There is a characteristic pattern of calcium influx in T lymphocytes and its sensitivity to potassium channel inhibition in HP that is missing in PE, raising the notion that T-lymphocyte calcium handling may have a role in the characteristic immune status of HP.
dc.relation.ispartof urn:issn:1046-7408
dc.title Lymphocyte calcium influx characteristics and their modulation by Kv1.3 and IKCa1 channel inhibitors in healthy pregnancy and preeclampsia
dc.type Journal Article 2016-08-19T09:05:27Z
dc.language.rfc3066 en
dc.identifier.mtmt 1470185
dc.identifier.wos 000286003000009
dc.identifier.pubmed 20649894
dc.contributor.department SE/AOK/K/I. Sz. Gyermekgyógyászati Klinika
dc.contributor.institution Semmelweis Egyetem

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