Basic aspects of the pharmacodynamics of tolperisone, a widely applicable centrally acting muscle relaxant

dc.contributor.author	Tekes Kornélia
dc.date.accessioned	2014-09-01T16:30:11Z
dc.date.available	2014-09-01T16:30:11Z
dc.date.issued	2014
dc.identifier.citation	pagination=17-22; journalVolume=8; journalTitle=THE OPEN MEDICINAL CHEMISTRY JOURNAL;
dc.identifier.uri	http://repo.lib.semmelweis.hu//handle/123456789/366
dc.identifier.uri	doi:10.2174/1874104501408010017
dc.description.abstract	Tolperisone (2-methyl-1-(4-methylphenyl)-3-piperidin-1-ylpropan-1-one hydro-chloride) was introduced in the clinical practice more than forty years ago and is still evaluated as a widely applicable compound in pathologically elevated skeletal muscle tone (spasticity) and related pains of different origin. In the present review, basic pharmacodynamic effects measured on whole animals, analyses of its actions on cell and tissue preparations and molecular mechanism of action on sodium and calcium channels are summarized as recently significantly new data were reported.
dc.relation.ispartof	urn:issn:1874-1045
dc.title	Basic aspects of the pharmacodynamics of tolperisone, a widely applicable centrally acting muscle relaxant
dc.type	Journal Article
dc.date.updated	2014-08-29T10:12:49Z
dc.language.rfc3066	en
dc.identifier.mtmt	2719492
dc.identifier.pubmed	25132868