HPLC determination of brain biogenic amines following treatment with bispyridinium aldoxime K203

dc.contributor.author	FARZAD HASHEMI
dc.contributor.author	Laufer Rudolf
dc.contributor.author	Szegi Péter
dc.contributor.author	Csomor V
dc.contributor.author	Kalász Huba
dc.contributor.author	Tekes Kornélia
dc.date.accessioned	2014-09-04T20:16:40Z
dc.date.available	2014-09-04T20:16:40Z
dc.date.issued	2014
dc.identifier.citation	pagination=40-46; journalVolume=101; journalIssueNumber=1; journalTitle=ACTA PHYSIOLOGICA HUNGARICA;
dc.identifier.uri	http://repo.lib.semmelweis.hu//handle/123456789/367
dc.identifier.uri	doi:10.1556/APhysiol.101.2014.1.5
dc.description.abstract	Effect of a new acetylcholine-esterase reactivator, K203 as a new potential antidote in organophosphate intoxications was studied on dopamine (DA), homovanillic acid (HVA), serotonin (5-HT) and 5-hydroxyindolacetic acid (5-HIAA) levels in seven brain regions (cerebellum, spinal cord, hippocampus, hypothalamus, striatum, medulla oblongata and frontal cortex) of rats by an optimized and validated HPLC method. No significant change in brain level of these neurotransmitters was found either 15 or 60 min following treatment. However, when 5-HIAA/5-HT ratios were calculated as measure of turnover, significant decreases were found in the cerebellum, hippocampus, hypothalamus and the frontal cortex 15 min following K203 administration, but after 60 min only in the frontal cortex.
dc.relation.ispartof	urn:issn:0231-424X
dc.title	HPLC determination of brain biogenic amines following treatment with bispyridinium aldoxime K203
dc.type	Journal Article
dc.date.updated	2014-09-02T12:57:30Z
dc.language.rfc3066	en
dc.identifier.mtmt	2556772
dc.identifier.wos	000332946400005
dc.identifier.pubmed	24631794
dc.contributor.department	SE/GYTK/Gyógyszerhatástani Intézet
dc.contributor.institution	Semmelweis Egyetem