dc.contributor.author |
Gonda, Xénia |
|
dc.contributor.author |
Kálmán, János |
|
dc.contributor.author |
Döme, Péter |
|
dc.contributor.author |
Rihmer, Zoltán |
|
dc.date.accessioned |
2016-12-05T13:50:39Z |
|
dc.date.available |
2016-12-05T13:50:39Z |
|
dc.date.issued |
2016 |
|
dc.identifier |
84961990433 |
|
dc.identifier.citation |
pagination=57-67;
journalVolume=18;
journalIssueNumber=1;
journalTitle=NEUROPSYCHOPHARMACOLOGIA HUNGARICA; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/3857 |
|
dc.description.abstract |
Bipolar disorder is a lifelong illness requiring lifelong pharmacotherapy. Therefore besides symptomatic remission, achievement of full work-related functioning and restoration of quality of life is a priority during successful treatment. The present prospective, observational, non-intervention study focused on investigating the effect of lamotrigine therapy on the quality of life and work-related function of bipolar patients in outpatient care. METHODS: 969 bipolar or schizoaffective outpatients participated in the study who previously did not receive lamotrigine therapy. Our present phase-prophylactic study was a prospective, observational, non-intervention study with a six-month follow-up. Evaluations took place at baseline and at months 1, 2, 3 and 6. Patients were followed with a Clinical Global Impression-Severity (CGI-S) and Clinical Global Impression-Improvement (CGI-I). Changes in work-related function was evaluated using Social Adjustment Scale (SAS), while quality of life was assessed with the Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q) scale. RESULTS: SAS scoreds showed a consistent decrease in the overall sample and in all CGI-S initial groups reflecting the improvement of work-related function during the six months of the follow-up. Q-LES-Q values in the whole sample and in all initial CGI-S groups showed a steady increase indicating a continuous increase in quality of life during the study. CONCLUSION: Our results indicate that during long-term prophylactic lamotrigine therapy the work function and quality of life of bipolar patients shows a significant improvement, therefore lamotrigine provides a possibility for full functional remission and restoration of quality of life. |
|
dc.relation.ispartof |
urn:issn:1419-8711 |
|
dc.title |
Az életminőség és a munkaképesség alakulása fázisprofilaktikus lamotriginkezelés során bipoláris betegekben: 6 hónapos, prospektív, obszervációs vizsgálat |
|
dc.type |
Journal Article |
|
dc.date.updated |
2016-11-22T08:23:52Z |
|
dc.language.rfc3066 |
hu |
|
dc.identifier.mtmt |
3055947 |
|
dc.identifier.pubmed |
27038871 |
|
dc.contributor.department |
SE/KSZE/Kútvölgyi Klinikai Tömb Klinikai és Kutatási Mentálhigiénés Osztály [2015.08.31] |
|
dc.contributor.department |
SE/GYTK/Gyógyszerhatástani Intézet |
|
dc.contributor.institution |
Semmelweis Egyetem |
|