dc.contributor.author |
Mellgren K |
|
dc.contributor.author |
Attarbaschi A |
|
dc.contributor.author |
Abla O |
|
dc.contributor.author |
Alexander S |
|
dc.contributor.author |
Bomken S |
|
dc.contributor.author |
Chiang A |
|
dc.contributor.author |
Csóka, Monika |
|
dc.contributor.author |
Fedorova A |
|
dc.contributor.author |
Kabickova E |
|
dc.contributor.author |
Kapuscinska-Kemblowska L |
|
dc.contributor.author |
Kobayashi R |
|
dc.contributor.author |
Krenova Z |
|
dc.contributor.author |
Meyer-Wentrup F |
|
dc.contributor.author |
Miakova N |
|
dc.contributor.author |
Pillon M |
|
dc.contributor.author |
Plat G |
|
dc.contributor.author |
Uyttebroeck A |
|
dc.contributor.author |
Williams D |
|
dc.contributor.author |
Wrobel G |
|
dc.contributor.author |
Kontny U |
|
dc.contributor.author |
European Intergroup for Childhood Non-Hodgkin Lymphoma (EICNHL) and the international Berlin-Frankfurt-Münster (i-BFM) Group |
|
dc.date.accessioned |
2017-02-01T14:31:19Z |
|
dc.date.available |
2017-02-01T14:31:19Z |
|
dc.date.issued |
2016 |
|
dc.identifier.citation |
pagination=1295-1305;
journalVolume=95;
journalIssueNumber=8;
journalTitle=ANNALS OF HEMATOLOGY; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/3887 |
|
dc.identifier.uri |
doi:10.1007/s00277-016-2722-y |
|
dc.description.abstract |
Peripheral T cell lymphomas (PTCL) are rare in children and adolescents, and data about outcome and treatment results are scarce. The present study is a joint, international, retrospective analysis of 143 reported cases of non-anaplastic PTCL in patients <19 years of age, with a focus on treatment and outcome features. One hundred forty-three patients, between 0.3 and 18.7 years old, diagnosed between 2000 and 2015 were included in the study. PTCL not otherwise specified was the largest subgroup, followed by extranodal NK/T cell lymphoma, hepatosplenic T cell lymphoma (HS TCL), and subcutaneous panniculitis-like T cell lymphoma (SP TCL). Probability of overall survival (pOS) at 5 years for the whole group was 0.56 +/- 0.05, and probability of event-free survival was (pEFS) 0.45 +/- 0.05. Patients with SP TCL had a good outcome with 5-year pOS of 0.78 +/- 0.1 while patients with HS TCL were reported with 5-year pOS of only 0.13 +/- 0.12. Twenty-five percent of the patients were reported to have a pre-existing condition, and this group had a dismal outcome with 5-year pOS of 0.29 +/- 0.09. The distribution of non-anaplastic PTCL subtypes in pediatric and adolescent patients differs from what is reported in adult patients. Overall outcome depends on the subtype with some doing better than others. Pre-existing conditions are frequent and associated with poor outcomes. There is a clear need for subtype-based treatment recommendations for children and adolescents with PTCL. |
|
dc.relation.ispartof |
urn:issn:0939-5555 |
|
dc.title |
Non-anaplastic peripheral T cell lymphoma in children and adolescents-an international review of 143 cases |
|
dc.type |
Journal Article |
|
dc.date.updated |
2016-11-28T14:21:56Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
3095927 |
|
dc.identifier.wos |
WOS:000379189100010 |
|
dc.identifier.pubmed |
27270301 |
|
dc.contributor.department |
SE/AOK/K/II. Sz. Gyermekgyógyászati Klinika |
|
dc.contributor.institution |
Semmelweis Egyetem |
|
dc.mtmt.swordnote |
CN European Intergroup for Childhood Non-Hodgkin Lymphoma (EICNHL) and the : international Berlin-Frankfurt-Munster (i-BFM) Group |
|
dc.mtmt.swordnote |
Dr. Csóka Monika nyilatkozom, hogy az alábbi közleményben szerzőként szerepelek. A közlemény tudományos együttműködés keretében született (nem study és nem szponzorált vizsgálat) és mind a mintagyűjtésben, mintafeldolgozásban, mind pedig a közleményhez szükséges adatfeldolgozásban és elemzésben aktív szerepem volt. 2017.01.30. |
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