dc.contributor.author |
Toldi, Gergely |
|
dc.contributor.author |
Saito S |
|
dc.contributor.author |
Shima T |
|
dc.contributor.author |
Halmos, Amrita |
|
dc.contributor.author |
Veresh, Zoltán |
|
dc.contributor.author |
Vásárhelyi, Barna |
|
dc.contributor.author |
Rigó, János |
|
dc.contributor.author |
Molvarec, Attila |
|
dc.date.accessioned |
2017-01-16T07:23:34Z |
|
dc.date.available |
2017-01-16T07:23:34Z |
|
dc.date.issued |
2012 |
|
dc.identifier |
84863877451 |
|
dc.identifier.citation |
pagination=175-180;
journalVolume=68;
journalIssueNumber=2;
journalTitle=AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/3930 |
|
dc.identifier.uri |
doi:10.1111/j.1600-0897.2012.01145.x |
|
dc.description.abstract |
PROBLEM: Regulatory T cells (Tregs) play an important role in the development of pregnancy-specific immune tolerance. We aimed to determine the peripheral frequency of a recently described Treg subpopulation, the CD4+ CD25- FoxP3+ Treg subset, and its correlation with the conventional CD4+ CD25high FoxP3+ Tregs in normal pregnancy (NP) and pre-eclampsia (PE) compared to non-pregnant (non-P) women. We also examined the proportion of the activated CD4+ CD25high FoxP3high Treg subset within conventional Treg cells. METHOD: We took peripheral blood samples from 20 PE, 20 NP, and 12 non-P women and determined the frequency of the above Treg subsets using flow cytometry. RESULTS: The frequency of conventional CD4+ CD25high FoxP3+ Tregs and activated CD4+ CD25high FoxP3high Tregs, but also that of non-conventional CD4+ CD25- FoxP3+ Tregs was higher in NP compared to non-P women, but lower again in PE, reaching comparable levels to the non-P group. The ratios of CD4+ CD25high FoxP3+ and CD4+ CD25- FoxP3+ Treg subsets were constant in all three investigated groups. CONCLUSION: Our results indicate that the frequency of conventional and non-conventional Tregs alters simultaneously, and the presence in circulation of both of these Treg subsets is similarly important in the adequate development of pregnancy-specific immune tolerance. |
|
dc.relation.ispartof |
urn:issn:1046-7408 |
|
dc.title |
The frequency of peripheral blood CD4+ CD25high FoxP3+ and CD4+ CD25- FoxP3+ regulatory T cells in normal pregnancy and pre-eclampsia. |
|
dc.type |
Journal Article |
|
dc.date.updated |
2016-12-09T10:58:23Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
1941716 |
|
dc.identifier.wos |
000306308200010 |
|
dc.identifier.pubmed |
22510013 |
|
dc.contributor.department |
SE/AOK/K/I. Sz. Gyermekgyógyászati Klinika |
|
dc.contributor.department |
SE/AOK/I/Laboratóriumi Medicina Intézet |
|
dc.contributor.department |
SE/AOK/K/I. Sz. Szülészeti és Nőgyógyászati Klinika |
|
dc.contributor.department |
SE/AOK/K/ISZGYK/MTA-SE Gyermekgyógyászati és Nephrológiai Kutatócsoport |
|
dc.contributor.institution |
Semmelweis Egyetem |
|