Terápiás hypothermia alkalmazása az asphyxiás újszülöttek kezelésében - egy hazai neonatológiai centrum eredményei

Abstract

INTRODUCTION AND AIM: We aimed to analyze patient characteristics of term neonates with hypoxic-ischemic encephalopathy treated with hypothermia at the 3rd level Neonatal Intensive Care Unit of the 1st Department of Pediatrics, Semmelweis University. METHOD: We conducted a retrospective cohort analysis between 2013-2015, including 97 asphyxiated neonates with HIE who received hypothermia treatment, using our in-house developed novel registry database. RESULTS: 59.8% of neonates were born with Cesarean section and the first blood gas analysis showed a pH of 7.0 +/- 0.2, pCO2 55.9 +/- 27.3 mmHg, base deficit 16.7 +/- 7.2 mmol/l, and lactate levels of 13.3 +/- 4.7 mmol/l (x +/- SD). Hypothermia treatment was started during neonatal transport in 93.7% of the cases, at 2.5 +/- 0.3 hours of age. Multiorgan failure associated with the perinatal asphyxia was present in 83.2% of the patients. Patients received intensive therapy for a median of 10.8 days, 61.3% of neonates were discharged home directly, 32.2% required further hospital treatment, and 6.5% died. CONCLUSION: Our novel registry database allowed for a quick, user-friendly and time-efficient analysis of patient characteristics in neonates with HIE. This registry could aid institutional audit work and prospective clinical data collection. Orv. Hetil., 2017, 158(9), 331-339.